Table 4 Additional specificity testing of aberrantly methylated genes in colon cancer in the test and validation sets
Specificity in colon cancer | ||||
|---|---|---|---|---|
Test set | Validation set | |||
Gene | Methylation negative | % | Methylation negative | % |
DKK3 | 27 of 27 | 100 | 24 of 31 | 77 |
ITIH5 | 24 of 27 | 89 | 22 of 31 | 71 |
WIF1 | 23 of 27 | 85 | n.d. | |
SFRP1 | 16 of 22 | 73 | n.d. | |
SFRP2 | 22 of 26 | 85 | n.d. | |
SFRP5 | n.d. | n.d. | ||
RASSF1A | n.d. | 13 of 31 | 42 | |
DKK3/ITIH5 a | 24 of 27 | 88 | 16 of 31 | 52 |
Three-gene panela | n.d. | 6 of 31 | 19 | |