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Table 2 Detection of aberrant gene promoter methylation in paired samples (serum and tumor) in the test set

From: Promoter hypermethylation of the tumor-suppressor genes ITIH5, DKK3, and RASSF1A as novel biomarkers for blood-based breast cancer screening

 

Sensitivity in

breast cancer serum

Sensitivity in

breast cancer tissue

Gene

Methylation

Positive

%

Methylation

positive

%

ITIH5

27 of 112

24

81 of 112

72

DKK3

37 of 112

33

97 of 112

87

WIF1

39 of 112

35

108 of 112

96

SFRP1

12 of 112

11

89 of 111

79

SFRP2

21 of 112

19

90 of 112

80

SFRP5

9 of 112

8

104 of 110

93

DKK3/ITIH5 a

46 of 112

41

105 of 112

94

  1. aEither gene methylated.