|  |  | Telomere FISHa | γH2AXb | COX-2b | αSMAb | CD31b | Immune infiltratec |
|---|
| Â | Low | 1 | 6 | 6 | 2 | 7 | 1 | 7 | 1 | 6 | 2 | 6 | 2 |
Activin A | High | 5 | 1 | 0 | 8 | 1 | 7 | 1 | 7 | 1 | 7 | 0 | 8 |
| Â | P value | 0.03 | 0.01 | 0.01 | 0.01 | 0.04 | 0.01 |
- aTelomere-specific fluorescence in situ hybridization (FISH) was evaluated on serial sections from each lesion. Lesions in which the telomere signals were equal or of greater intensity than adjacent stroma were scored as high. Lesions in which the telomere signal was less than the adjacent stroma were scored as low. bProtein levels were evaluated by using immunohistochemistry (IHC) on serial sections from each lesion and scored as absent to low (low) or moderate to high (high). cImmune infiltrate was evaluated on serial sections of each lesion stained with H&E and scored as absent to low (low) or moderate to high (high). P values were calculated by using a two-sided Fisher Exact Test.
