Figure 5
From: Cell-extrinsic consequences of epithelial stress: activation of protumorigenic tissue phenotypes
Direct DNA damage in human mammary fibroblasts (HMFs) alters the expression of molecules associated with desmoplasia. RM9, RM15, or RM156 HMFs treated with etoposide (double-stranded breaks), NU7026 (DNA-PK inhibitor), or UVC (single-stranded breaks) at the indicated doses. Average values (triplicates) for (A) fibronectin (FN1), (B) tenascin C (TenC), (F) HIF1α, and (H) COX-2 mRNAs or (duplicates) for (C) IL-8, (D) IL-6, (E) VEGF, and (G) activin A proteins are shown relative to untreated controls at each time point. The horizontal gray line indicates no change, and red markers show statistically significant differences compared with control.