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Figure 4 | Breast Cancer Research

Figure 4

From: Interplay between neural-cadherin and vascular endothelial-cadherin in breast cancer progression

Figure 4

Significant suppression of neural (N)-cadherin in Ep5ExTu cells influences β-catenin localization and the level of epithelial-mesenchymal transition (EMT) regulator genes in Ep5ExTu cells. (a) Immunolocalization of β-catenin in the Sh-Scr cell line and Sh-N-cadherin cell lines (Sh-N-cad1.1, Sh-N-cad1.2 and Sh-N-cad2). Ep5 cells were used as a positive control for the localization of β-catenin in epithelial cell lines that have not undergone EMT. Bar, 30 μm. (b) and (c) mRNA level of Snail, vimentin and Smad interacting protein 1 (SIP1) in Ep5ExTu clones. (d), (e) and (f) the bars indicate the relative expression levels of snail, vimentin and SIP1 mRNA in three independent experiments. β-actin was used as loading control. The mean ± SD is (*, P < 0.0491 and **, P < 0.0014) (n = 3).

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