Skip to main content

Table 4 Evaluation of acquisition parameters on the association between adjusted mammographic densitya estimated from enrollment (screen-film) mammograms and risk of breast cancer in the Mayo Mammography Health Study cohort (2003 to 2009)

From: The influence of mammogram acquisition on the mammographic density and breast cancer association in the mayo mammography health study cohort

     Models with addition of acquisition parameters
    Models with no acquisition parameters kVp - 3 levels mAs Thickness Compression All 4 acquisitionparameters
Percent density Number of cases Person-years in Subcohort HRb(95% CI) HRb(95% CI) HRb(95% CI) HRb(95% CI) HRb(95% CI) HRb(95% CI)
0% to 5.0% 42 2,071.0 1.00 (Ref.) 1.00 (Ref.) 1.00 (Ref.) 1.00 (Ref.) 1.00 (Ref.) 1.00 (Ref.)
5.1% to 15.0% 76 2,678.7 1.89 (1.28, 2.80) 1.89 (1.28, 2.79) 1.88 (1.27, 2.78) 1.88 (1.27, 2.78) 1.90 (1.28, 2.80) 1.88 (1.27, 2.79)
15.1% to 25.0% 53 2,327.7 1.88 (1.22, 2.91) 1.86 (1.20, 2.88) 1.86 (1.21, 2.88) 1.88 (1.22, 2.90) 1.89 (1.22, 2.92) 1.88 (1.21, 2.92)
25.1% + 83 2,511.6 3.57 (2.30, 5.55) 3.51 (2.23, 5.48) 3.51 (2.25, 5.48) 3.60 (2.32, 5.59) 3.54 (2.28, 5.50) 3.56 (2.22, 5.69)
kVp    - 1.04 (0.87, 1.25) - - - 1.01 (0.82, 1.24)
mAs    - - 1.04 (0.89, 1.21) - - 1.00 (0.79, 1.26)
Thickness, mm    - - - 1.08 (0.92, 1.26) - 1.06 (0.83, 1.35)
Compression, pounds    - - - - 0.93 (0.82, 1.06) 0.94 (0.82, 1.07)
C-statistic    0.64 0.64 0.64 0.63 0.64 0.63
BI-RADS         
1 41 2,082.8 1.00 (Ref.) 1.00 (Ref.) 1.00 (Ref.) 1.00 (Ref.) 1.00 (Ref.) 1.00 (Ref.)
2 106 3,778.4 1.63 (1.13, 2.35) 1.62 (1.12, 2.33) 1.62 (1.12, 2.33) 1.63 (1.13, 2.35) 1.64 (1.13, 2.36) 1.61 (1.11, 2.33)
3 87 3,078.4 2.04 (1.37, 3.03) 1.98 (1.32, 2.97) 2.00 (1.34, 2.98) 2.04 (1.38, 3.04) 2.04 (1.37, 3.03) 1.96 (1.30, 2.98)
4 20 649.3 2.72 (1.53, 4.81) 2.62 (1.47, 4.68) 2.65 (1.49, 4.71) 2.78 (1.57, 4.94) 2.69 (1.52, 4.77) 2.56 (1.38, 4.75)
kVp -   - 1.07 (0.89, 1.28) - - - 1.06 (0.84, 1.33)
mAs    - - 1.06 (0.91, 1.23) - - 1.05 (0.85, 1.29)
Thickness, mm    - - - 1.07 (0.92, 1.25) - 0.99 (0.78, 1.27)
Compression, pounds    - - - - 0.92 (0.81, 1.05) 0.92 (0.80, 1.05)
C-statistic    0.62 0.62 0.62 0.62 0.62  
  1. aAnalyses adjusted for age, menopausal status, post-menopausal hormone use, and body mass index. bHazard ratios (HRs) corresponding to milliampere-seconds (mAs), thickness, and compression refer to a 1 standard deviation (SD) change in the respective parameter (SD: mAs = 49.5, thickness = 12.7, compression = 5.6). HRs corresponding to voltage peak (kVp) are based on a tri-level ordinal variable (22-25, 26-27, 28-32). Owing to missing acquisition parameters, 18 cases and 47 controls that were included in the analyses depicted in Table 2 are not included here. BI-RADS, Breast Imaging Reporting and Data System; CI, confidence interval; Ref., reference value.