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Table 3 Mean case risk percentiles for BCRAT and IBIS among subgroups of subjects.

From: Breast cancer risk assessment across the risk continuum: genetic and nongenetic risk factors contributing to differential model performance

  N BCRAT IBIS Pvalueª
Age (yrs) at risk assignment
<35 7 18.8 31.2 0.2969
35-49 38 56.9 66.9 0.0377
50+ 38 77.7 79.1 0.7489
Age (yrs) at first menarche
<14 yrs 67 63.6 69.7 0.0717
> = 14 or unknown 16 61.2 68.6 0.4637
Age (yrs) at FLB
<25 yrs 20 67.7 61.3 0.2268
> = 25 or nulliparous 63 61.8 72.1 0.0022
Menopausal status
Pre 43 51.8 61.9 0.0196
Post 40 75.4 77.6 0.6064
HRT use
Never 59 58.3 66.8 0.0149
Ever 24 75.1 76.1 0.9119
Number of breast biopsies
0 61 56.4 68.7 0.0001
1+ 22 81.9 71.7 0.0118
BMI (kg/m²)
<25 48 62.5 65.6 0.9919
> = 25 35 64.1 74.8 0.0014
First-degree female relatives with BC
0 26 45.1 56.8 0.0967
1+ 57 71.4 75.2 0.1816
Second/third-degree relatives with BC
0 37 67.4 70.7 0.7617
1+ 46 59.8 68.5 0.0185
Relatives with OC
0 61 65.4 67.5 0.5412
1+ 22 57.0 75.1 0.0094
BRCA mutation status
Test result positive 14 61.4 98.1 0.0001
Test result negative 37 68.8 65.5 0.1457
Untested 32 57.5 61.6 0.1823
Ethnicity
Non-Hispanic White 74 65.2 72.1 0.0638
Other 9 46.6 48.1 0.4961
  1. ªUsing Wilcoxon signed rank test. BC, breast cancer; FLB, first live birth; HRT, hormone replacement therapy; OC, ovarian cancer.