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Table 2 Ten-year breast cancer risks as observed and assigned by BCRAT and IBIS.

From: Breast cancer risk assessment across the risk continuum: genetic and nongenetic risk factors contributing to differential model performance

  

Observed risk (%)

Assigned risk (%)

Observed/Assigned

All subjects

N

Risk

CI

BCRAT

IBIS

BCRAT

IBIS

Age (yrs) at risk assignment

Ratio

Ratio

<35

471

1.91

0.91-3.98

0.58

2.11

3.29

0.91

35-49

769

7.03

5.06-9.68

2.96

6.13

2.38

1.15

50+

617

8.49

6.16-11.59

5.43

7.26

1.56

1.17

Age (yrs) at first menarche

<14 yrs

1416

6.67

5.24-8.47

3.31

5.64

2.02

1.18

> = 14 or unknown

441

4.54

2.74-7.45

2.74

4.98

1.66

0.91

Age (yrs) at FLB

<25 yrs

576

4.98

3.15-7.79

4.05

4.93

1.23

1.01

> = 25 or Nulliparous

1281

6.71

5.23-8.58

2.79

5.73

2.41

1.17

Menopausal status

Pre

1190

5.13

3.77-6.94

2.04

4.51

2.51

1.14

Post

667

8.13

5.95-11.00

5.2

7.22

1.56

1.13

HRT use

Never

1488

5.59

4.3-7.24

2.79

5.07

2.00

1.10

Ever

369

8.56

5.74-12.60

4.74

7.16

1.81

1.20

Number of breast biopsies

0

1546

5.72

4.42-7.36

2.63

5.04

2.17

1.13

1+

311

8.7

5.72-13.02

5.87

7.72

1.48

1.13

BMI (kg/m²)

<25

1098

5.80

4.36-7.67

2.98

5.25

1.95

1.05

> = 25

759

7.04

4.99-9.85

3.46

5.83

2.03

1.21

First-degree female relatives with BC

0

641

5.84

3.93-8.61

1.67

3.43

3.50

1.70

1+

1261

6.48

4.98-8.38

3.97

6.57

1.63

0.99

Second/third-degree relatives with BC

0

969

5.64

4.04-7.81

3.41

5.35

1.65

1.05

1+

888

6.83

5.10-9.09

2.92

5.64

2.34

1.21

All relatives with OC

0

1395

6.09

4.72-7.84

3.26

4.53

1.87

1.34

1+

463

6.72

4.38-10.17

2.92

8.37

2.30

0.80

BRCA mutation status

Test result positive

110

16.29

9.70-26.07

3.77

33.8

4.32

0.48

Test result negative

690

6.24

4.53-8.54

3.63

3.66

1.72

1.70

Untested

1057

5

3.46-7.17

2.82

3.73

1.77

1.34

Race/Ethnicity

Non-Hispanic White

1270

7.09

5.65-8.85

3.52

6.15

2.01

1.15

Other

587

2.6

1.18-5.63

2.43

4.06

1.07

0.64

  1. BC, breast cancer; FLB, first live-birth; HRT, hormone replacement therapy; OC, ovarian cancer.