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Table 2 Interaction between presence of estrogen receptor (ER) and p53 expression

From: Prognostic interaction between expression of p53 and estrogen receptor in patients with node-negative breast cancer: results from IBCSG Trials VIII and IX

 

Hazard ratio

95% Confidence interval

P-value

Disease-free survival models1

   

p53 univariate (positive vs negative)

1.128

0.902, 1.410

0.3

ER univariate (present vs absent)

0.850

0.663, 1.090

0.2

Without interaction

   

p53

1.044

0.815, 1.339

0.7

ER

0.866

0.660, 1.138

0.3

With interaction

   

p53

0.606

0.390, 0.942

0.03

ER

0.606

0.431, 0.851

0.004

Inter p53/ER2

2.152

1.278, 3.623

0.004

With pathological variables3

   

p53

0.575

0.368, 0.896

0.01

ER

0.747

0.517, 1.081

0.12

Inter p53/ER

1.968

1.156, 3.352

0.01

Grade 1

1.00

Reference

0.00094

Grade 2

1.463

1.018, 2.104

 

Grade 3

1.988

1.362, 2.903

 

Vascular invasion5

1.314

1.040, 1.661

0.02

With pathological and treatment variables

   

p53

0.581

0.373, 0.906

0.02

ER

0.957

0.608, 1.507

0.85

Inter p53/ER

1.941

1.139, 3.307

0.01

Grade 1

1.00

Reference

0.0009

Grade 2

1.458

1.014, 2.097

 

Grade 3

1.988

1.361, 2.904

 

Vascular Invasion

1.305

1.033, 1.650

0.03

Tmt Endocrine only6

1.688

1.081, 2.636

0.02

Inter Tmt/ER7

0.595

0.360, 0.984

0.04

OS models

   

p53 univariate

0.985

0.731, 1.326

0.9

ER univariate

0.667

0.493, 0.901

0.008

Without interaction

   

p53

0.783

0.561, 1.092

0.15

ER

0.599

0.430, 0.836

0.003

With interaction

   

p53

0.460

0.273, 0.777

0.004

ER

0.434

0.295, 0.638

<0.0001

Inter p53/ER

2.350

1.225, 4.507

0.01

With pathological variables

   

p53

0.426

0.252, 0.719

0.001

ER

0.498

0.325, 0.763

0.001

Inter p53/ER

2.293

1.187, 4.433

0.01

T < = 1 cm

1.00

Reference

0.003

T >1 to 2 cm

1.858

0.932, 3.706

 

T > 2 cm

2.682

1.340, 5.368

 

Grade 1

1.00

Reference

0.11

Grade 2

1.578

0.957, 2.604

 

Grade 3

1.759

1.041, 2.973

 

Vascular invasion

1.309

0.971, 1.764

0.08

With pathological and treatment variables

   

p53

0.427

0.253, 0.723

0.002

ER

0.604

0.355, 1.028

0.06

Inter p53/ER

2.280

1.179, 4.409

0.01

T < = 1 cm

1.00

Reference

0.002

T > 1 to 2cm

1.929

0.965, 3.856

 

T > 2 cm

2.762

1.378, 5.536

 

Grade 1

1.00

Reference

0.11

Grade 2

1.573

0.954, 2.594

 

Grade 3

1.749

1.034, 2.957

 

Vascular invasion

1.295

0.961, 1.745

0.09

Tmt endocrine only

1.574

0.931, 2.659

0.09

Inter Tmt/ER

0.666

0.363, 1.222

0.19

  1. 1Stratified by trial. 2Interaction term reflects cases with both expression of p53 and presence of ER. 3Tumor size was not significant and was dropped from the disease-free survival model. 4Peritumoral vascular invasion at central pathology review. 5P-values for multi-level variables (tumor size and grade) reflect overall significance. 6Treatment allocation endocrine only (goserelin in trial VIII, tamoxifen in trial IX) without chemotherapy. 7No interaction was seen between p53 status and the presence or absence of chemotherapy (data not shown). Inter, interaction (as detected by statistical analysis); Tmt, treatment allocation.