Table 1 Significant upregulated and downregulated functional gene networks of the migratory breast tumor cells

1

48

DNA replication and repair

ALDOA, CDC25A, CDK1, CKS1B, CSDE1, DAZAP2, DBP, EMP1, FOXM1, IFI16, NCL, NONO, NPM1, PMAIP1, POLR2G, PTAFR, S100A11, SET, SF3B2, SKP1, SLC20A1, TRIM32, UBC, XRCC5

2

36

Embryonic and tissue development

ACVR1B, ARHGDIB, CAP1, CAV1, CDC42, DDX24, FADD, GLO1, IL8, KLF11, LSM3, MSN, NCAPD3, PPM1A, PTPN11, RPS6, SMAD2, SNRPD1, SNRPD3, SNTB2, UTRN, VAMP7, YWHAE

3

33

Cellular movement and development

ARHGAP11A, CNN3, ITGAE, MRPL27, OSGEP, PHACTR2, PRDX5, RFC3, RPL30, RPL37, RPL12, SNRPD3, TUBA1A, TUBA4A, TXNDC9, UBE2D3, ZNF184

4

33

Cell-to-cell signaling and interaction

ACAP2, ASPH, CALU, COX7B, GARS, IMPDH2, ISLR, NOP10, PRDX3, RABIF, RPL11, RPL19, SDHD, STRBP, USP13, WBP5, ZNF207

5

27

Cellular assembly and organization

ATP5G1, ATP5I, ATP6V0A1, DDAH1, DGUOK, ERH, FMOD, MYL12A, PSMB2, PSME2, SF3B14, STXBP2, TBCA, UQCR10, VAMP7

Downregulated

1

44

Nervous system development and function

AKAP13, BBS2, CEACAM6, CHP, CREB1, DLG1, HSPB6, IL11, IL32, INA, ITGB3BP, NUP62, PNRC1, S1PR2, SH3BP2, SLC2A3, SLCO1B3, STAR, TNFRSF9, TRIM13, VDR

2

31

Cell death and cell cycle

ACRBP, ATP8A1, BCL7B, DOC2B, GOSR1, IREB2, MIB2, NDUFB2, PSMD5, RASA4, RPL37, SLC2A3, TGFB1I1, TNF, TP53I3, TP53INP1, TST, TTF1, YTHDC1

3

22

Hematologic disease

CHP, CNN2, F11, FRG1, GATAD2B, HSDL2, KCNJ9, POFUT1, SGCB, TSPAN14, ZFC3H1, ZNF165

4

19

Protein synthesis and cell morphology

EIF4A1, EPB49, HEBP2, MACF1, MLL4, MPRIP, MYO1C, RAG1AP1, TES, UBR5, ZNF790

5

18

Drug and nucleic acid metabolism

IL10RB, MDM2, NAIP, PIP5K1C, PPFIBP1, SLC25A37, SLC2A3, SLC38A2, SNRNP70, STK25, ZNF331