Polymorphisms in hormone metabolism and growth factor genes and mammographic density in Norwegian postmenopausal hormone therapy users and non-users

Table 4 Top twenty single nucleotide polymorphisms (SNPs) that showed the strongest heterogeneity in association between never hormone therapy users (N = 1,008) and postmenopausal current estrogen and progestin users (N = 248), by P for interaction.

Gene	SNP	SNPs per gene	Alleles	WW	WV+VV	Beta	SE	P¹	Pb²	Pint³
PRL	rs10946545	34	G/A	219	29	10.86	3.04	0.0004	0.0144	0.0008
ESR2	rs12434245	29	C/T	216	32	-8.09	2.94	0.0063	0.1839	0.0034
TNF	rs3093553	15	T/G	228	20	-9.86	3.63	0.0070	0.1050	0.0046
CYP1A1/CYP1A2	rs3743	13	G/C	233	15	-9.79	4.16	0.0194	0.2524	0.0061
TNF	rs3093662	15	A/G	225	23	-8.53	3.42	0.0133	0.2002	0.0064
TNF	rs4947324	15	C/T	214	34	-8.53	2.89	0.0035	0.0520	0.0154
PRL	rs2744117	34	G/T	212	36	7.97	2.80	0.0048	0.1633	0.0206
ESR2	rs7159462	29	C/T	214	34	-6.61	2.87	0.0222	0.6447	0.0248
PRL	rs1156546	34	A/C	163	85	4.77	2.09	0.0230	0.7812	0.0249
SHBG	rs6258	13	C/T	246	2	23.25	11.09	0.0370	0.4815	0.0345
ESR2	rs10137185	29	C/T	209	39	-5.20	2.73	0.0575	1.6684	0.0425
PGR	rs569857	32	T/A	217	31	-5.69	3.02	0.0603	1.9306	0.0434
PPARG	rs4279078	32	G/A	203	45	6.09	2.58	0.0190	0.6082	0.0442
PPARG	rs2960420	32	C/G	111	137	-4.60	1.99	0.0219	0.6997	0.0458
VEGF	rs699946	21	A/G	159	89	-3.96	2.08	0.0587	1.2333	0.0719
PGR	rs7106686	32	G/A	188	60	-4.46	2.32	0.0559	1.7873	0.0854
PRL	rs9358533	34	C/T	207	41	6.45	2.66	0.0159	0.5413	0.0927
PGR	rs507141	32	G/A	185	63	4.40	2.28	0.0550	1.7594	0.1431
PGR	rs5181	32	C/G	208	40	-5.58	2.72	0.0411	1.3164	0.1753
PRL	rs1205960	34	C/T	140	108	-3.86	2.01	0.0559	1.8994	0.1765

¹From linear regression models using percent mammographic density as the outcome variable. Adjusted for age and BMI in a dominant model of inheritance. ²Bonferroni-adjusted P values. ³P for interaction for EPT vs. never HT users in all postmenopausal women (N = 2,036).

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