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Table 3 Top twenty single nucleotide polymorphism (SNPs) in postmenopausal current estrogen-only users (N = 78) that showed the strongest heterogeneity between never hormone therapy users and estrogen-only users.

From: Polymorphisms in hormone metabolism and growth factor genes and mammographic density in Norwegian postmenopausal hormone therapy users and non-users

Gene

SNP

SNPs per gene

Alleles

WW

WV+VV

Beta1

SE

P1

Pb2

Pint3

PPARG

rs1175543

32

A/G

42

36

-9.80

3.00

0.0017

0.0535

0.0028

CYP1B1

rs4670813

17

G/A

25

53

-9.99

3.17

0.0023

0.0396

0.0059

CYP1B1

rs162550

17

G/C

44

34

8.19

3.11

0.0103

0.1753

0.0068

ESR2

rs1256063

29

G/A

65

13

12.27

4.00

0.0030

0.0868

0.0069

IGFBP1/IGFBP3

rs1496497

29

G/A

47

31

-8.08

3.13

0.0119

0.3464

0.0155

IL6

rs6949149

19

G/T

70

8

-12.82

4.97

0.0119

0.2256

0.0206

TGFB1

rs8179181

11

A/T

48

30

7.91

3.16

0.0144

0.1579

0.0214

ESR1

rs2295190

12

G/T

51

27

-6.45

3.36

0.0590

0.7086

0.0293

PPARG

rs1151996

32

A/C

36

42

-7.18

3.11

0.0236

0.7554

0.0520

CYP1B1

rs1625

17

T/G

49

29

6.74

3.25

0.0418

0.7098

0.0557

TGFB1

rs1982072

11

A/T

35

43

-6.32

3.17

0.0498

0.5478

0.0577

CYP1A1/CYP1A2

rs11072507

13

C/G

39

39

7.26

3.24

0.0281

0.3656

0.0578

CYP1B1

rs162557

17

G/A

47

31

6.05

3.21

0.0635

1.0791

0.0622

IGFBP1/IGFBP3

rs10241749

29

A/G

49

29

7.10

3.35

0.0375

1.0878

0.0657

PPARG

rs2120825

32

T/G

56

22

8.12

3.42

0.0201

0.6421

0.0733

COMT

rs12627876

29

C/T

77

1

26.61

13.83

0.0582

1.6881

0.0827

CYP1A1/CYP1A2

rs2606345

13

A/C

38

40

7.00

3.09

0.0263

0.3415

0.0886

IGFBP1/IGFBP3

rs4619

29

A/G

28

50

-6.51

3.31

0.0531

1.5400

0.0950

HSD3B1/HSD3B2

rs6428828

3

A/T

38

40

5.77

3.08

0.0650

0.1951

0.0954

PRL

rs1123886

34

T/C

36

42

6.22

3.17

0.0533

1.8109

0.2058

  1. 1From linear regression models using percent mammographic density as the outcome variable. Adjusted for age and BMI in a dominant model of inheritance. See Table S2 in Additional file 2 for the stratum-specific results in never HT users. 2Bonferroni-adjusted P values. 3P for interaction for ET vs. never HT users in all postmenopausal women (N = 2,036).