Factors | No. patients | Â | Univariate | Â | Â | Multivariate | Â |
---|---|---|---|---|---|---|---|
 |  | HR | 95% CI | P-value | HR | 95% CI | P-value |
Age (years) | Â | Â | Â | Â | Â | Â | Â |
<40 | 66 | 1 | Â | Â | 1 | Â | Â |
41 to 55 | 187 | 0.97 | 0.64 to 1.49 | 0.90 | 1.05 | 0.68 to 1.64 | 0.81 |
56 to 70 | 179 | 0.79 | 0.51 to 1.23 | 0.29 | 0.81 | 0.40 to 1.66 | 0.57 |
>70 | 120 | 0.59 | 0.35 to 0.99 | 0.05 | 0.59 | 0.27 to 1.28 | 0.18 |
Menopausal status | Â | Â | Â | Â | Â | Â | Â |
Premenopausal | 215 | 1 | Â | Â | 1 | Â | Â |
Postmenopausal | 337 | 0.76 | 0.57 to 1.00 | 0.05 | 0.99 | 0.56 to 1.74 | 0.98 |
Tumor size | Â | Â | Â | Â | Â | Â | Â |
pT1, <2 cm | 251 | 1 | Â | Â | 1 | Â | Â |
pT2, >2 to <5 | 276 | 1.12 | 0.84 to 1.49 | 0.43 | 1.09 | 0.82 to 1.46 | 0.34 |
pT3, >5 + pT4 | 25 | 1.62 | 0.84 to 3.11 | 0.15 | 1.92 | 0.99 to 3.75 | 0.06 |
Grade | Â | Â | Â | Â | Â | Â | Â |
Poor | 257 | 1 | Â | Â | 1 | Â | Â |
Good/Moderate | 124 | 0.53 | 0.35 to 0.79 | 0.002 | 0.56 | 0.37 to 0.85 | 0.007 |
Unknown | 171 | 1.06 | 0.78 to 1.44 | 0.70 | 1.20 | 0.87 to 1.64 | 0.26 |
PGR status (mRNA) | Â | Â | Â | Â | Â | Â | Â |
Negative | 116 | 1 | Â | 1 | Â | Â | Â |
Positive | 436 | 0.67 | 0.49 to 0.92 | 0.013 | 0.71 | 0.51 to 0.99 | 0.04 |
ERBB2 status (mRNA) | Â | Â | Â | Â | Â | Â | Â |
Negative | 475 | 1 | Â | Â | 1 | Â | Â |
Positive | 77 | 1.51 | 1.06 to 2.15 | 0.02 | 1.39 | 0.97 to 2.00 | 0.08 |
 |  |  |  |  | Addition to the base model | ||
TWIST1 mRNA level†(Continuous) | 552 | 1.34 | 1.17 to 1.53 | <0.001 | 1.32 | 1.14 to 1.53 | <0.001 |
TWIST1 mRNA level †|  |  |  |  |  |  |  |
TWIST1 quartile 1 | 135 | 1 | Â | Â | 1 | Â | Â |
TWIST1 quartile 2 | 125 | 1.02 | 0.65 to 1.61 | 0.92 | 0.90 | 0.57 to 1.43 | 0.67 |
TWIST1 quartile 3 | 149 | 1.28 | 0.85 to 1.94 | 0.24 | 1.09 | 0.71 to 1.68 | 0.70 |
TWIST1 quartile 4 | 143 | 2.06 | 1.39 to 3.04 | <0.001 | 1.87 | 1.25 to 2.80 | 0.002 |