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Figure 4 | Breast Cancer Research

Figure 4

From: High TWIST1 mRNA expression is associated with poor prognosis in lymph node-negative and estrogen receptor-positive human breast cancer and is co-expressed with stromal as well as ECM related genes

Figure 4

Representative tissues with IHC staining of TWIST1 protein. A: Strong nuclear staining of TWIST1 protein in an ER-positive tumor tissue with high TWIST1 mRNA expression. B: Weak nuclear staining of TWIST1 protein in an ER-negative tumor tissue with low TWIST1 mRNA expression. C: Correlation of TWIST1 mRNA expression and protein expression in breast tumor tissues (n = 20; n = 10 high TWIST1 mRNA expression, n = 10 low TWIST1 mRNA expression). Red and green boxes represent high and low TWIST1 mRNA expressing tumor tissues, respectively, whereas empty boxes and filled boxes represent ER-negative and ER-positive tumor tissues, respectively. Spearman rank correlation test was used to evaluate the correlation between TWIST1 mRNA and protein expression. D: Association of stromal staining of TWIST1protein with ER-positive tumor tissues. (▽ = negative nuclei of inflammatory cells; ▼ = strong positive nuclei of inflammatory cells; ↕ = strong positive nuclei of fibroblast; ⇨ = strong positive nuclei of tumor cells; ↓ = strong positive nuclei of endothelial cells).

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Breast Cancer Research

ISSN: 1465-542X

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