Variation in breast cancer risk associated with factors related to pregnancies according to truncating mutation location, in the French National BRCA1 and BRCA2 mutations carrier cohort (GENEPSO)

Lecarpentier, Julie; Noguès, Catherine; Mouret-Fourme, Emmanuelle; Gauthier-Villars, Marion; Lasset, Christine; Fricker, Jean-Pierre; Caron, Olivier; Stoppa-Lyonnet, Dominique; Berthet, Pascaline; Faivre, Laurence; Bonadona, Valérie; Buecher, Bruno; Coupier, Isabelle; Gladieff, Laurence; Gesta, Paul; Eisinger, François; Frénay, Marc; Luporsi, Elisabeth; Lortholary, Alain; Colas, Chrystelle; Dugast, Catherine; Longy, Michel; Pujol, Pascal; Tinat, Julie; Lidereau, Rosette; Andrieu, Nadine

doi:10.1186/bcr3218

Table 3 Risk of breast cancer associated with incomplete pregnancies and the TMAP score.

From: Variation in breast cancer risk associated with factors related to pregnancies according to truncating mutation location, in the French National BRCA1 and BRCA2 mutations carrier cohort (GENEPSO)

Reproductive factors		One woman per family cohort: 39,666 person-years of follow-up					*BRCA1*mutation carriers: 25,045 person-years of follow-up					*BRCA2*mutation carriers: 14,621 person-years of follow-up
		Person-years^a	No. of cases^a	HR	95% CI	Pvalue	Person-years^a	No. of cases^a	HR	95% CI	Pvalue	Person-years^a	No. of cases^a	HR	95% CI	Pvalue
Incomplete pregnancies ^b
	Never	33,455	219	1.00			21,291	135	1.00			12,164	84	1.00
	Ever	5,995	155	1.28	0.98-1.67	0.07	3,673	103	1.30	0.95-1.76		2,322	52	1.07	0.64-1.78
No. of incomplete pregnancies ^b
	0	33,455	219	1.00			21,291	135	1.00			12,164	84	1.00
	1	4,208	103	1.25	0.93-1.69		2,544	70	1.27	0.89-1.82		1,664	33	0.96	0.53-1.73
	2	1,320	32	1.07	0.69-1.66		841	21	1.08	0.65-1.79		479	11	1.01	0.46-2.24
	≥3	467	20	2.39	1.28-4.45	0.01	288	12	2.45	1.19-5.04	0.02	179	8	2.69	0.71-10.3
	Trend			1.19	1.02-1.39	0.03			1.20	1.00-1.43	0.05			1.15	0.84-1.58
Type of incomplete pregnancies ^b
	No incomplete pregnancies	33,384	219	1.00			21,220	135	1.00			12,164	84	1.00
	Induced abortion only	2,909	71	1.29	0.93-1.81		1,859	50	1.35	0.92-1.99		1,050	21	1.02	0.53-1.96
	Miscarriage only	2,494	65	1.19	0.83-1.72		1,407	41	1.14	0.73-1.78		1,087	24	1.05	0.54-2.04
	Induced abortion and miscarriage	535	18	1.49	0.84-2.65		350	11	1.51	0.79-2.91		185	7	1.43	0.45-4.51
No. of induced abortions^b
	0	35,968	286	1.00			22,666	177	1.00			13,302	109	1.00
	1	2,833	66	1.15	0.83-1.60		1,805	47	1.22	0.84-1.78		1,028	19	0.87	0.45-1.68
	2	497	16	1.44	0.74-2.78		322	10	1.59	0.75-3.40		175	6	1.47	0.44-4.88
	≥3	114	7	3.84	1.52-9.66	<10^-3	82	4	3.31	1.13-9.71	0.03	32	3	7.85	1.74-35.5	0.01
	Trend			1.28	1.04-1.58	0.02			1.32	1.04-1.67	0.02			1.26	0.81-1.95
No. of miscarriages^b
	0	36,419	293	1.00			23,121	186	1.00			13,298	107	1.00
	1	2,273	64	1.21	0.85-1.72		1,321	41	1.20	0.79-1.82		952	23	1.01	0.50-2.02
	2	508	12	0.98	0.48-1.99		301	6	0.69	0.27-1.81		207	6	1.54	0.64-3.67
	≥3	248	7	1.18	0.42-3.30		135	5	1.40	0.44-4.53		113	2	0.86	0.10-7.56
	Trend			1.07	0.87-1.32				1.04	0.81-1.35				1.09	0.75-1.58
Age at first induced abortion^c
	<20 years	1,094	32	1.00			662	20	1.00			432	12	1.00
	≥ 20 years	2,350	57	0.50	0.28-0.90	0.02	1,547	41	0.53	0.27-1.02	0.06	803	16	0.40	0.10-1.53
	No induced abortion	35,968	286	0.74	0.31-1.78		22,666	177	0.70	0.27-1.84		13,302	109	1.10	0.12-10.5
Age at first miscarriage^c
	<20 years	220	5	1.00			202	5	1.00			18	0
	≥ 20	2,809	78	1.04	0.25-4.28		1,555	47	0.87	0.20-3.73		1,254	31
	No miscarriage	36,419	293	0.81	0.17-3.99		23,121	186	0.69	0.12-3.93		13,298	107
Induced abortion relative to the first full-term pregnancy^b
	No induced abortion	35,964	284	1.00			22,663	175	1.00			13,301	109	1.00
	Before first full-term pregnancy	1,835	49	1.77	1.19-2.63	0.01	1,223	33	1.77	1.13-2.77	0.01	612	16	1.88	0.86-4.12
	After first full-term pregnancy	1,613	42	0.97	0.65-1.45		989	30	1.14	0.72-1.79		624	12	0.55	0.26-1.18
Miscarriage relative to the first full-term pregnancy^b 1.00
	No miscarriage	36,414	291				23,118	186	1.00			13,296	105	1.00
	Before first full-term pregnancy	1,138	29	1.07	0.65-1.77		729	20	1.01	0.55-1.84		409	9	0.89	0.36-2.16
	After first full-term pregnancy	1,896	56	1.05	0.73-1.51		1,031	32	1.02	0.65-1.60		865	24	1.09	0.57-2.08
Type and length of incomplete pregnancies^b
	No abortion	33,384	219	1.00			21,220	135	1.00			12,164	84	1.00
	Induced abortion only	2,909	71	1.30	0.93-1.82		1,859	50	1.36	0.92-2.00		1,050	21	1.01	0.52-1.95
	Miscarriage with length ≤3 months	2,492	74	1.35	0.95-1.93	0.09	1,461	45	1.27	0.84-1.94		1,031	29	1.35	0.69-2.67
	Miscarriage with length >3 months	436	8	0.93	0.41-2.12		253	7	1.17	0.47-2.95		183	1	0.14	0.02-1.24	0.08
TMAP score (not including never pregnant women)^d
	]0-0.35]	7,545	141	1.00			4,564	85	1.00			2,981	56	1.00
	]0.35-0.40]	3,416	88	1.05	0.75-1.48		2,154	59	0.99	0.66-1.48		1,262	29	1.09	0.60-1.98
	]0.40-0.45]	1,735	51	1.23	0.81-1.86		1,034	30	1.12	0.67-1.87		701	21	1.33	0.68-2.59
	]0.45-0.50]	589	17	1.53	0.80-2.93		433	14	1.41	0.68-2.92		156	3	1.70	0.37-7.71
	]0.5-1.00]	1,186	22	1.97	1.19-3.29	0.01	722	12	1.91	1.07-3.42	0.03	464	10	2.04	0.79-5.24
	Trend			1.16	1.03-1.30	0.02			1.14	0.99-1.32	0.07			1.17	0.95-1.44

^a Not including missing data. ^bAdjusted for parity (0, 1, 2, ≥3), menopausal status (yes, no), oral contraceptives (never, ever), and gene mutated (BRCA1, BRCA2). ^cAdjusted for parity (0,1 2, ≥3), no. of incomplete pregnancies (0, 1, 2, ≥3), menopausal status (yes, no), oral contraceptives (never, ever), and gene mutated (BRCA1, BRCA2). ^dAdjusted for menopausal status (yes, no), oral contraceptives (never, ever), and gene mutated (BRCA1, BRCA2). HR, hazard ratio; CI, confidence interval.

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