Downregulation of the tumor-suppressor miR-16 via progestin-mediated oncogenic signaling contributes to breast cancer development

Table 1 Tumor growth rates^a.

Treatment	Mean tumor volume (mm³)	Growth rate (mm³/day)	Growth inhibition (%)	Delay in tumor growth (days)
pre-miR-CTRL-C4HD	683.6 ± 192.2*	26.1*
pre-miR-16-C4HD	231.1 ± 107.9^#	9.6^#	66.2^b	5^b

^aGrowth rates were calculated as the slopes of growth curves. The volume, percentage of growth inhibition, and delay in tumor growth (days) in tumors from mice injected with pre-miR16-C4HD cells relative to mice injected with pre-miR-CTRL-C4HD cells were calculated at day 28, as described in Methods. *P < 0.01, **P < 0.001 versus pre-miR-CTRL-C4HD-treated cells. ^bRelative to pre-miR-CTRL-C4HD-treated cells, P < 0.001.

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