From: Reproductive aging-associated common genetic variants and the risk of breast cancer
 |  | Quintile of GRS |  | ||||
---|---|---|---|---|---|---|---|
 | Continuous GRS | Quintile 1 | Quintile 2 | Quintile 3 | Quintile 4 | Quintile 5 | Pfor trend |
Count GRSa | Â | Â | Â | Â | Â | Â | Â |
Age at menarche | Â | Â | Â | Â | Â | Â | Â |
   Cases/Controls | 3,683/34,174 | 677/6,694 | 739/6,814 | 731/6,788 | 783/6,915 | 753/6,963 |  |
   Mean/Median GRS (range)b | 20.41 (9.12-31.95) | 17.00 (9.12-18.09) | 19.02 (18.09-19.86) | 20.37 (19.86-21.05) | 21.90 (21.05-22.74) | 23.89 (22.74-31.95) |  |
   OR (95% CI)c | 1.01 (1.00-1.03) | 1.00 | 1.10 (0.97-1.24) | 1.01 (0.89-1.14) | 1.14 (1.01-1.28) | 1.13 (1.00-1.27) | 0.06 |
Age at natural menopause | Â | Â | Â | Â | Â | Â | Â |
   Cases/Controls | 3,683/34,174 | 740/6,699 | 751/6,948 | 719/6,787 | 755/6,929 | 718/6,811 |  |
   Mean/Median GRS (range)b | 16.21 (4.15-26.52) | 12.95 (4.15-14.01) | 14.91 (14.01-15.62) | 16.15 (15.62-16.90) | 17.64 (16.90-18.37) | 19.55 (18.37-26.52) |  |
   OR (95% CI)c | 1.00 (0.98-1.01) | 1.00 | 1.02 (0.90-1.15) | 0.93 (0.82-1.05) | 1.02 (0.90-1.14) | 0.98 (0.87-1.11) | 0.54 |
Breast cancer | Â | Â | Â | Â | Â | Â | Â |
   Cases/Controls | 3,683/34,174 | 537/6,864 | 542/6,525 | 660/6,716 | 956/7,352 | 988/6,717 |  |
   Mean/Median GRS (range)b | 8.88 (1.06-16.96) | 6.04 (1.06-7.01) | 7.99 (7.01-8.05) | 8.99 (8.05-9.07) | 9.99 (9.07-10.86) | 11.31 (10.86-16.96) |  |
   OR (95% CI)c | 1.13 (1.11-1.15) | 1.00 | 1.19 (1.04-1.37) | 1.38 (1.21-1.57) | 1.60 (1.41-1.81) | 1.89 (1.67-2.14) | 1.5 × 10-31 |
Weighted GRSa | Â | Â | Â | Â | Â | Â | Â |
Age at menarche | Â | Â | Â | Â | Â | Â | Â |
   Cases/Controls | 3,683/34,174 | 762/8,961 | 711/6,811 | 752/6,287 | 728/6,059 | 736/6,056 |  |
   Mean/Median GRS (range)b | 20.03 (7.15-32.17) | 16.12(7.15-17.50) | 18.47 (17.50-19.31) | 20.07 (19.31-20.83) | 21.63 (20.83-22.55) | 23.82 (22.55-32.17) |  |
   OR (95% CI)c | 1.01 (1.00-1.03) | 1.00 | 1.02 (0.90-1.15) | 0.99 (0.88-1.13) | 1.02 (0.90-1.16) | 1.11 (0.98-1.26) | 0.12 |
Age at natural menopause | Â | Â | Â | Â | Â | Â | Â |
   Cases/Controls | 3,683/34,174 | 749/7,038 | 728/6,915 | 756/6,749 | 696/6,668 | 755/6,804 |  |
   Mean/Median GRS (range)b | 14.32 (2.78-26.21) | 11.13 (2.78-12.18) | 12.96 (12.18-13.61) | 14.24 (13.61-14.88) | 15.57 (14.88-16.39) | 17.63 (16.39-26.21) |  |
   OR (95% CI)c | 1.00 (0.98-1.01) | 1.00 | 1.07 (0.95-1.20) | 0.97 (0.86-1.09) | 1.00 (0.88-1.13) | 1.03 (0.91-1.16) | 0.73 |