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Table 3 Association between genetic risk score and risk of breast cancer

From: Reproductive aging-associated common genetic variants and the risk of breast cancer

  

Quintile of GRS

 
 

Continuous GRS

Quintile 1

Quintile 2

Quintile 3

Quintile 4

Quintile 5

Pfor trend

Count GRSa

       

Age at menarche

       

   Cases/Controls

3,683/34,174

677/6,694

739/6,814

731/6,788

783/6,915

753/6,963

 

   Mean/Median GRS (range)b

20.41 (9.12-31.95)

17.00 (9.12-18.09)

19.02 (18.09-19.86)

20.37 (19.86-21.05)

21.90 (21.05-22.74)

23.89 (22.74-31.95)

 

   OR (95% CI)c

1.01 (1.00-1.03)

1.00

1.10 (0.97-1.24)

1.01 (0.89-1.14)

1.14 (1.01-1.28)

1.13 (1.00-1.27)

0.06

Age at natural menopause

       

   Cases/Controls

3,683/34,174

740/6,699

751/6,948

719/6,787

755/6,929

718/6,811

 

   Mean/Median GRS (range)b

16.21 (4.15-26.52)

12.95 (4.15-14.01)

14.91 (14.01-15.62)

16.15 (15.62-16.90)

17.64 (16.90-18.37)

19.55 (18.37-26.52)

 

   OR (95% CI)c

1.00 (0.98-1.01)

1.00

1.02 (0.90-1.15)

0.93 (0.82-1.05)

1.02 (0.90-1.14)

0.98 (0.87-1.11)

0.54

Breast cancer

       

   Cases/Controls

3,683/34,174

537/6,864

542/6,525

660/6,716

956/7,352

988/6,717

 

   Mean/Median GRS (range)b

8.88 (1.06-16.96)

6.04 (1.06-7.01)

7.99 (7.01-8.05)

8.99 (8.05-9.07)

9.99 (9.07-10.86)

11.31 (10.86-16.96)

 

   OR (95% CI)c

1.13 (1.11-1.15)

1.00

1.19 (1.04-1.37)

1.38 (1.21-1.57)

1.60 (1.41-1.81)

1.89 (1.67-2.14)

1.5 × 10-31

Weighted GRSa

       

Age at menarche

       

   Cases/Controls

3,683/34,174

762/8,961

711/6,811

752/6,287

728/6,059

736/6,056

 

   Mean/Median GRS (range)b

20.03 (7.15-32.17)

16.12(7.15-17.50)

18.47 (17.50-19.31)

20.07 (19.31-20.83)

21.63 (20.83-22.55)

23.82 (22.55-32.17)

 

   OR (95% CI)c

1.01 (1.00-1.03)

1.00

1.02 (0.90-1.15)

0.99 (0.88-1.13)

1.02 (0.90-1.16)

1.11 (0.98-1.26)

0.12

Age at natural menopause

       

   Cases/Controls

3,683/34,174

749/7,038

728/6,915

756/6,749

696/6,668

755/6,804

 

   Mean/Median GRS (range)b

14.32 (2.78-26.21)

11.13 (2.78-12.18)

12.96 (12.18-13.61)

14.24 (13.61-14.88)

15.57 (14.88-16.39)

17.63 (16.39-26.21)

 

   OR (95% CI)c

1.00 (0.98-1.01)

1.00

1.07 (0.95-1.20)

0.97 (0.86-1.09)

1.00 (0.88-1.13)

1.03 (0.91-1.16)

0.73

  1. aSee the 'Materials and methods' section for count genetic risk score (GRS) and weighted GRS computation; bmean for continuous GRS and median for each quintile; cadjusted for age and potential population stratification. CI, confidence interval; OR, odds ratio.