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Figure 9 | Breast Cancer Research

Figure 9

From: Insulin-like growth factor 1 attenuates antiestrogen- and antiprogestin-induced apoptosis in ER+ breast cancer cells by MEK1 regulation of the BH3-only pro-apoptotic protein Bim

Figure 9

A schematic representation of the role of BimEL and induction of apoptosis in ER+ breast cancer cells. This model is a summary of data showing that MEK1 blockade, in addition to hormonal treatment (antiestrogen or antiprogestin treatment) will activate Bim via dephosphorylation and induce an ROS-dependent apoptotic cell death in some ER+ breast cancer cells, particularly if IGF-1-induced IGF-IR signaling is active.

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Breast Cancer Research

ISSN: 1465-542X

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