Table 3 Correlations of cancer-adjacent gene expression with biologically relevant signatures, by microenvironment subtype and tumor characteristics
From: Gene expression in extratumoral microenvironment predicts clinical outcome in breast cancer patients
Microenvironment subtype | Tumor subtype/tumor characteristics | ||||||
|---|---|---|---|---|---|---|---|
Signature | Number of genesa | Active N (%) N= 27 | Inactive N (%) N= 45 | Claudin low N (%) N= 9 | Non- Claudin low N (%) N= 63 | ER positiveb N (%) N= 44 | ER negative N (%) N= 22 |
TWIST | 831/794/664 | ||||||
positive | 25 (92.6) | 7 (15.6) | |||||
negative | 2 (7.4) | 38 (84.4) | |||||
P = 5.7e-11 | |||||||
Claudin Low | 807/754/478 | ||||||
Positive | 26 (96.3) | 7 (15.6) | 6 (66.7) | 27 (42.9) | |||
Negative | 1 (3.7) | 38 (84.4) | 3 (33.3) | 36 (57.1) | |||
P = 3.6e-12 | P = 0.28 | ||||||
TGFβ | 217/207/181 | ||||||
Positive | 18 (66.7) | 15 (33.3) | |||||
Negative | 9 (33.3) | 30 (66.7) | |||||
P = 7.7e-3 | |||||||
DTF | 511/451/351 | ||||||
Positive | 16 (59.3) | 16 (35.6) | |||||
Negative | 11 (40.7) | 29 (64.4) | |||||
P = 0.086 | |||||||
ER Response | 754/700/407 | ||||||
positive | 14 (51.9) | 21 (46.7) | 25 (56.8) | 5 (22.7) | |||
negative | 13 (48.1) | 24 (53.3) | 19 (43.2) | 17 (77.3) | |||
P = 0.80 | P = 0.010 | ||||||