Relevance of PTEN loss in brain metastasis formation in breast cancer patients

Breast Cancer Research

Table 1 Statistically significantly different regions between primary breast tumors and brain metastases

Chrom. region^a		bp start	bp end	Size (Mbp)	% del PT	% gain PT	% del MET	% gain MET	Pvalue	Fdr
1	p22.1-21.2	94472000	101828000	7.4	25.8	3.2	0.0	20.0	0.005	0.04
7	p22.1-15.2	5383000	27787000	22.4	3.2-12.9	12.9	0.0	70.0-80.0	0.001-0.002	0.01-0.02
	p11.2	54565000	55475001	0.5	0.0	9.7-12.9	0.0	70.0	0.001-0.003	0.01-0.02
10	pter-p12.1	173000	28895000	28.7	0.0	0.0	20.0	40.0	0.005	0.04
	q11.22-q21.1	49685000	59935000	10.3	3.2	6.5	60.0	20.0	0.005	0.04
	q22.1-qter	71226000	134848000	63.6	0-12.9	3.2-6.5	60.0-90.0	0.0-10.0	0.001-0.002	0.02
11	pter-p15.4	188000	9693000	9.5	12.9-19.4	9.7-12.9	70.0	0.0	0.001-0.005	0.01-0.04
16	q24.2	87416000	87465000	0.0	87.1	0.0	30.0	0.0	0.002	0.02
17	q11.2	26591000	29500000	2.9	16.1-22.6	25.8-29.0	70.0	0.0	0.001-0.005	0.01-0.04

fdr, false discovery rate; MET, brain metastasis; PT, primary tumor. ^aThe complete region that was statistically significantly different between the two groups (primary versus metastasis). Therefore, some break points in some patients might occur within the region, causing a variation in the frequencies of deletions/amplifications within a region and P values and fdr.

ISSN: 1465-542X