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Table 1 Selected up-regulated proteins in tamoxifen resistant breast cancer cells

From: Proteomic analysis of acquired tamoxifen resistance in MCF-7 cells reveals expression signatures associated with enhanced migration

Accession

# AAs

MW

(kDa)

Description

Gene symbols

Fold change TamR/Ctrl

t-test

(P- values)

Relapse free survival analysis (Logrank P)

IPI00025311

584

61.7

Breast carcinoma-amplified sequence 1

bcas1

11.28

1.3E-06

-3.2E-5

IPI00017526

95

10.4

Protein S100-P

s100p

5.20

2.3E-08

1.7E-6

IPI00218831

218

25.7

Glutathione S-transferase Mu 1

gstm1

3.70

8.6E-07

-3.8E-11

IPI00183695

97

11.2

Protein S100-A10

s100a10

3.15

1.0E-07

2.3E-5

IPI00922108

1002

111.1

Integrin alpha-V

itgav

2.88

7.8E-06

2.0E-9

IPI00021267

976

108.2

Ephrin type-A receptor 2

epha2

2.81

3.1E-05

-2.0E-9

IPI00027341

348

38.5

Macrophage-capping protein

capg

2.80

2.3E-07

3.9E-5

IPI00106687

222

25.7

Latexin

lxn

2.69

1.3E-05

0.2

IPI00013895

105

11.7

Protein S100-A11

s100a11

2.51

3.0E-05

5.1E-10

IPI00455315

339

38.6

Annexin A2

anxa2

2.41

2.7E-08

0.93

IPI00297910

323

35.7

Tumor-associated calcium signal transducer 2

tacstd2

2.19

1.1E-06

0.53

IPI00903145

583

68.5

Radixin

rdx

2.17

2.4E-06

0.25

IPI00219301

332

31.5

Myristoylated alanine-rich C-kinase substrate

marcks

2.14

6.9E-06

-0.17

IPI00853146

167

19.2

Caveolin

cav

2.08

1.0E-03

-4.2E-8

IPI00215995

1051

116.5

Integrin alpha-3

itga3

2.00

2.0E-04

-3.9E-9

IPI00010414

329

36.0

PDZ and LIM domain protein 1

pdlim1

1.94

1.8E-06

-0.009

IPI00795633

448

52.3

Clusterin

clu

1.88

1.5E-04

-0.02

IPI00010214

104

11.7

Protein S100-A14

s100a14

1.87

2.1E-04

0.96

IPI00465431

250

26.1

Galectin-3

lgals3

1.79

2.5E-06

0.28

IPI00219219

135

14.7

Galectin-1

lgals1

1.78

2.0E-04

0.008

IPI00018364

183

20.5

Ras-related protein Rap-2b

rap2b

1.71

7.5E-05

6.7E-6

IPI00016485

394

42.7

Protein phosphatase slingshot homolog 3

ssh3

1.68

1.1E-03

-2.4E-11

IPI00217563

798

88.4

Integrin beta-1

itgb1

1.64

3.8E-08

6.9E-12

IPI00180240

44

5.1

Thymosin beta-4-like protein 3

tmsl3

1.63

3.7E-07

1.7E-5

IPI00641181

195

19.5

MARCKS-related protein

marcksl1

1.55

3.6E-06

0.011

IPI00759759

327

37.1

Epidermal growth factor receptor kinase substrate 8-like protein 2

eps8l2

1.53

2.4E-03

-0.13

IPI00021828

98

11.1

Cystatin-B

cstb

1.52

4.2E-04

4.7E-5

IPI00001871

340

36.5

PRKC apoptosis WT1 regulator protein

pawr

1.47

1.9E-04

0.23

IPI00843975

586

69.4

Ezrin

ezr

1.41

4.0E-04

1.8E-5

IPI00847442

92

10.1

FK506 binding protein12

fkbp12

1.40

1.4E-05

0.0011

IPI00022462

760

84.8

Transferrin receptor protein 1

tfrc

1.40

1.2E-05

0.00049

IPI00005585

124

13.7

Tax1-binding protein 3

tax1bp3

1.39

5.5E-06

6.7E-6

IPI00016179

98

11.5

Protein S100-A13

s100a13

1.39

7.6E-09

0.15

IPI00005202

247

26.2

Membrane-associated progesterone receptor component 2

pgrmc2

1.38

2.2E-04

3.6E-5

IPI00015148

184

20.8

Ras-related protein Rap-1b

rap1b

1.36

5.7E-06

2.3E-5

IPI00291175

1066

116.6

Vinculin

vcl

1.35

2.3E-05

-0.11

IPI00375426

323

36.2

Cathepsin H

ctsh

1.34

3.6E-04

-0.44

IPI00011285

714

81.8

Calpain-1 catalytic subunit

capn1

1.33

6.1E-06

-0.22

IPI00020599

417

48.1

Calreticulin

calr

1.31

3.3E-06

0.67

IPI00009342

1657

189.1

Ras GTPase-activating-like protein IQGAP1

iqgap1

1.29

7.9E-07

1.0E-4

IPI00010080

527

58.0

Serine/threonine-protein kinase OSR1

oxsr1

1.28

5.0E-04

0.49

IPI00478231

193

21.8

Transforming protein RhoA

rhoa

1.28

4.8E-07

0.016

IPI00012011

166

18.5

Cofilin-1

cfl1

1.28

1.5E-05

-7.9E-8

IPI00025084

268

28.3

Calpain small subunit 1

capn2

1.26

1.4E-05

-1.6E-12

IPI00013808

911

104.8

Alpha-actinin-4

actn4

1.24

1.5E-04

0.64

IPI00000513

821

90.9

E-cadherin

cdh1

1.24

6.6E-05

1.5E-7

IPI00220739

195

21.7

Membrane-associated progesterone receptor component 1

pgrmc1

1.23

1.1E-03

5.7E-7

IPI00028091

418

47.3

Actin-related protein 3

actr3

1.23

4.8E-04

2.4E-14

IPI00217519

206

23.6

Ras-related protein Ral-A

rala

1.21

3.6E-03

< 1.0E-16

IPI00922213

1014

111.2

fibronectin 1

fn1

1.19

3.4E-02

0.46

IPI00220847

1745

194.3

Integrin beta-4

itgb4

1.19

6.3E-04

-0.12

IPI00016786

191

21.2

Cell division control protein 42 homolog

cdc42

1.15

5.2E-05

-4.3E-10