Skip to main content

Table 2 Mutation spectra for the TP53 gene

From: Immunohistochemical detection of Polo-like kinase-1 (PLK1) in primary breast cancer is associated with TP53mutation and poor clinical outcome

Site of Mutation

Effect

PLK Neg (0-3)

PLK1 Pos (4-18)

Exon 4

Deletion

1

0

Exon 5

Missense

11

6

 

Nonsense

1

0

Exon 6

Missense

5

0

 

Nonsense

2

1

Exon 7

Deletion

7

2

Exon 8

Missense

9

2

Exon 9

Nonsense

1

0

Exon 10

Deletion

1

0

 

Missense

2

0

Intron 5

Frame Shift

2

0

Intron 6

Frame Shift

1

1

Intron 9

Frame Shift

1

0

*Exon 5 and 6

Missense, Silent

1

0

*Exon 7, 8 and 9

Missense, Missense, Silent

1

0

  

46

12

  1. * Tumours where multiple mutations were present