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Table 4 In vivo internal water reference method breast cancer literature published to date

From: In vivo proton magnetic resonance spectroscopy of breast cancer: a review of the literature

Study

B0

n

Method

Breast cancer [Cho] range

Sensitivity

Specificity

Bolan et al. 2003 [32]

4 T

28

SV

0.5-8.6 mmol/kg

46%

94%

Baik et al. 2006 [55]

1.5 T

32

SV

0.76-21.20 mmol/kg

NA

NA

Baek et al. 2008 [56]

1.5 T

32

SV

0.32-10.47 mmol/kg

NA

NA

Sijens et al. 2010 [21]

1.5 T

2

MRSI

4.1 and 4.6 mmol/kg

NA

NA

Chen et al. 2011 [31]

1.5 T

45

SV

0.08-9.99 mmol/kg

NA

NA

Dorrius et al. 2011 [22]

1.5 T

24

MRSI

1.7-11.8 mmol/kg

100%

100%

Thakur et al. 2011 [57]

1.5 T

57

SV

0-47.1 mmol/kg

75-96%a

93-100%a

  1. aDepending upon choline concentration ([Cho]) cutoff value. n = number of participants with breast cancer contributing to reported [Cho] range. B0, field strength. MRSI, magnetic resonance spectroscopic imaging; NA, not applicable; SV, single-voxel; T, Tesla.