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Table 2 FISH* analysis of HER2 gene copy number in AU565WT, AU565TR and AU565LR cells

From: A novel inhibitor of fatty acid synthase shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines

CELL LINES

AU565WT

AU565TR

AU565LR

Ratio of average HER2 to average CEN17 gene copy number

4.9

3.9

4.4

  1. AU565WT, AU565 Wild Type; AU565TR, AU565 cells resistant to trastuzumab; AU565LR, AU565 cells resistant to lapatinib;
  2. * FISH, fluorescence in situ hybridisation; HER2/CEN17 > 2 indicates HER2 gene amplification.