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Table 2 Multivariate Cox regression survival analysis of the PTEN promoter variants, adjusted for common prognostic factors.

From: Variants on the promoter region of PTEN affect breast cancer progression and patient survival

10-year breast cancer specific

  

5-year BDDM

   

Category

P-value

HR

95% CI

Category

P-value

HR

95% CI

Tumor size

1.67 × 10-6

  

Tumor size

9.89 × 10-13

  

2 vs 1

0.0006

1.92

1.32 to 2.79

2 vs 1

1.73 × 10-6

2.4

1.68 to 3.44

3 vs 1

4.12 × 10-6

4.27

2.30 to 7.92

3 vs 1

2.38 × 10-8

5.21

2.92 to 9.30

4 vs 1

0.0001

3.80

1.95 to 7.41

4 vs 1

3.49 × 10-11

6.63

3.79 to 11.61

Nodal metastasis

1.70 × 10-10

3.57

2.41 to 5.27

Nodal metastasis

4.03 × 10-10

3.08

2.17 to 4.39

Distant metastasis

4.63 × 10-10

5.51

3.22 to 9.42

    

progesterone receptor

0.0025

1.69

1.20 to 2.38

progesterone receptor

0.0398

1.39

1.02 to 1.91

Grade

2.12 × 10-5

  

Grade

0.0001

  

2 vs 1

0.3528

1.31

0.74 to 2.31

2 vs 1

0.0111

2.07

1.18 to 3.63

3 vs 1

0.0004

2.76

1.57 to 4.86

3 vs 1

4.78 × 10-5

3.25

1.84 to 5.74

PTEN promoter variant

0.0119

2.01

1.17 to 3.46

PTEN promoter variant

0.0381

1.79

1.03 to 3.11

  1. Models were built for 10-year breast cancer specific survival (left) and for 5-year breast cancer death or distant metastasis free survival (right). Factors included in the analysis were tumor size, nodal status, primary metastasis (for 10-year breast cancer specific only), estrogen receptor, progesterone receptor, Her2, p53, Ki67, and grade. Only the variables significant in the final step of the model are presented in the tables, demonstrating that carrying any of the PTEN promoter variants is an independent prognostic factor.
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Breast Cancer Research

ISSN: 1465-542X

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