Table 1 Identification and description of cadherins present in the mammary gland and altered in breast cancer
From: The role and function of cadherins in the mammary gland
Cadherin | Name | Classification | Localization in the mammary gland | Involvement in breast cancer |
|---|---|---|---|---|
CDH1 | E-cadherin | Classical type I | Luminal epithelial | Downregulated and overexpression, somatic mutations |
CDH2 | N-cadherin | Classical type I | Nerve and mesenchymal | Upregulated |
CDH3 | P-cadherin | Classical type I | Myoepithelial, ducts and alveoli | Upregulated |
CDH4 | R-cadherin | Classical type I | Epithelial | Downregulated |
CDH5 | VE-cadherin | Classical type II | Vascular endothelial | Overexpression and misexpressed |
CDH11 | OB-cadherin | Classical type II | Unknown | Upregulated in epithelial |
CDH13 | T/H-cadherin | Classical type III | Ductal epithelium, endothelial and smooth muscle cells | Downregulated/decreased expression, promoter methylation |
CDH15 | M-cadherin | Classical type III | Unknown | Downregulated, LOH |
FAT4 | Protocadherin Fat4 | Fat and Daschous | Epithelial | Downregulated, promoter methylation |
PCDH8 | Protocadherin-8 | Protocadherin | Luminal epithelial | Downregulated, somatic missense, LOH, homozygous deletion, promoter methylation |
PCDH10 | OL-protocadherin | Protocadherin | Epithelial | Downregulated, frequent promoter methylation |
DSG2 | Desmoglein-2 | Desmosomal | Epithelial | Unknown |
DSC3 | Desmocollin-3 | Desmosomal | Epithelial | Downregulated, promoter methylation |