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Figure 5 | Breast Cancer Research

Figure 5

From: Replacement of E-cadherin by N-cadherin in the mammary gland leads to fibrocystic changes and tumor formation

Figure 5

Cyst formation in Ncadk.i. and Ncadk.i.;p53 mammary glands. With increasing lactation cycles, the accumulation of fibrous tissue was accompanied by the formation of cysts. After ten lactation cycles, H&E-stained paraffin sections showed cyst formation in both Ncadk.i. and Ncadk.i.;p53 mammary glands, while no cysts were observed in controls. Premalignant marks, such as calcification (arrows) and accumulation of necrotic material (arrowheads), were detected in both lines. Cyst formation was accompanied by a downregulation of CFTR. Oil Red staining showed the accumulation of lipids in alveolar epithelial cells in Ncadki. and Ncadk.i;p53 mammary glands. Scale bar: 100 μm. CFTR, Cystic Fibrosis Transmembrane Conductance Regulator; H&E, Hematoxylin and Eosin; Ncadk.i., WAP::Cre;EcadNcad/fl; Ncadk.i.;p53, WAP::Cre;EcadNcad/fl;p53fl/+.

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