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Table 2 Frequency of Ala592Thr variant in various populations of breast cancer patients and control population

From: Low frequency of E-cadherinalterations in familial breast cancer

 

No of families/

Frequency of

  

Screened population

no of cases

Ala592Thr variant

Case id

Histopathology

Familial breast cancer

    

   Non-BRCA1/BRCA2 mutation carrier

358

0.56%

311-89D

Ductal comedo

   

AL-155

Ductal comedo

BRCA1/BRCA2 carrier

126

0.79%

BR-115

Ductal comedo

   

BR-119

Ductal comedo

Sporadic breast cancer

    

   Early-onset breast cancer

214

-

  

   Unselected breast cancer

604

0.83%

17-S

Lobular

   

MB-181

Ductal comedo

   

MB-483

Ductal

   

ULL-17

Ductal

   

ULL-284

Ductal

Control population

495

0.80%