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Figure 6 | Breast Cancer Research

Figure 6

From: β1 integrin mediates an alternative survival pathway in breast cancer cells resistant to lapatinib

Figure 6

AIIB2 neutralizes the upregulated pFAK and pSrc expression found in LTRes cells. (A) Parental and LTRes cells were grown on lrECM with AIIB2 or IgG, propagated for five days, and probed for markers. (B) The FAK inhibitor was applied to parental and LTRes cells on Day 0 of plating on lrECM and allowed to grow for 12 days. (C) 3D cultures were harvested for protein and probed for phospho- and total EGFR, HER2, and HER3.

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