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Figure 4 | Breast Cancer Research

Figure 4

From: β1 integrin mediates an alternative survival pathway in breast cancer cells resistant to lapatinib

Figure 4

β1 inhibition impedes colony grow of BT474 LRes and LTRes cells, but not parental or TRes. (A) Parental, LRes, LTRes, and TRes cells were plated in lrECM, subjected to HER2 and/or β1 inhibitors on Day 0, and propagated for 10 to 12 days. (B) The Hs_ITGB1_5 siRNA was validated both in 2D and 3D (top), transfected at 40 nMsi into parental, LRes, LTRes, and TRes cells, which were then grown on lrECM for 10 days (bottom).

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