From: Tribbles homolog 3 denotes a poor prognosis in breast cancer and is involved in hypoxia response
 | DFS | OS | ||||||
---|---|---|---|---|---|---|---|---|
Factor | Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | ||||
 | P -value | HR (95% CI)a | P -value | HR (95% CI)a | P -value | HR (95% CI)a | P -value | HR (95% CI)a |
Age (years) | 0.036 | Â | 0.008 | Â | 0.939 | Â | Â | Â |
   41-55 vs. ≤40 |  | 0.59 (0.30-1.17) |  | 0.38 (0.18-0.79) |  | 1.10 (0.44-2.76) |  |  |
   56-70 vs. ≤40 |  | 0.58 (0.31-1.12) |  | 0.53 (0.27-1.06) |  | 0.93 (0.38-2.28) |  |  |
   > 70 vs. ≤40 |  | 0.30 (0.13-0.69) |  | 0.20 (0.07-0.55) |  | 0.89 (0.33-2.41) |  |  |
Menopausal status | 0.024 | Â | Â | Â | 0.255 | Â | Â | Â |
   Post- vs. premenopausal |  | 0.77 (0.61-0.96) |  |  |  | 0.73 (0.42-1.25) |  |  |
Tumor size | 0.006 | Â | 0.023 | Â | 0.111 | Â | Â | Â |
   pT2 vs. pT1 |  | 2.15 (1.17-3.95) |  | 2.36 (1.20-4.65) |  | 1.59 (0.82-3.07) |  |  |
   pT3+4 vs. pT1 |  | 2.81 (1.40-5.62) |  | 2.87 (1.30-6.37) |  | 2.23 (1.04-4.77) |  |  |
Histological grade | 0.091 | Â | Â | Â | 0.768 | Â | Â | Â |
   II vs. I |  | 1.54 (0.36-6.58) |  |  |  | 1.38 (0.32-5.94) |  |  |
   III vs. I |  | 2.80 (0.68-11.6) |  |  |  | 1.76 (0.42-7.44) |  |  |
Number of involved lymph nodes | 0.001 | Â | 0.013 | Â | 0.005 | Â | 0.006 | Â |
   1-3 vs. node-negative |  | 1.51 (0.89-2.56) |  | 1.41 (0.81-2.44) |  | 1.39 (0.73-2.65) |  | 1.53 (0.80-2.93) |
   ≥4 vs. node-negative |  | 3.29 (1.84-5.88) |  | 2.63 (1.38-5.00) |  | 3.32 (1.67-6.64) |  | 3.17 (1.56-6.43) |
Estrogen receptor statusb | 0.245 | Â | Â | Â | 0.845 | Â | Â | Â |
   Positive vs. negative |  | 0.77 (0.50-1.19) |  |  |  | 0.95 (0.55-1.63) |  |  |
Progestrone receptor statusb | 0.431 | Â | Â | Â | 0.650 | Â | Â | Â |
   Positive vs. negative |  | 0.84 (0.55-1.29) |  |  |  | 0.89 (0.53-1.48) |  |  |
TRIB3 | < 0.001 | Â | 0.009 | Â | < 0.001 | Â | < 0.001 | Â |
   Higher vs. lower than median |  | 2.15 (1.39-3.31) |  | 1.90 (1.17-3.08) |  | 3.48 (2.00-6.06) |  | 3.90 (2.06-7.37) |