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Table 2 Cox uni- and multivariate analyses of disease-free survival (DFS) and overall survival (OS) in all patients (n = 247).

From: Tribbles homolog 3 denotes a poor prognosis in breast cancer and is involved in hypoxia response

 

DFS

OS

Factor

Univariate analysis

Multivariate analysis

Univariate analysis

Multivariate analysis

 

P -value

HR (95% CI)a

P -value

HR (95% CI)a

P -value

HR (95% CI)a

P -value

HR (95% CI)a

Age (years)

0.036

 

0.008

 

0.939

   

   41-55 vs. ≤40

 

0.59 (0.30-1.17)

 

0.38 (0.18-0.79)

 

1.10 (0.44-2.76)

  

   56-70 vs. ≤40

 

0.58 (0.31-1.12)

 

0.53 (0.27-1.06)

 

0.93 (0.38-2.28)

  

   > 70 vs. ≤40

 

0.30 (0.13-0.69)

 

0.20 (0.07-0.55)

 

0.89 (0.33-2.41)

  

Menopausal status

0.024

   

0.255

   

   Post- vs. premenopausal

 

0.77 (0.61-0.96)

   

0.73 (0.42-1.25)

  

Tumor size

0.006

 

0.023

 

0.111

   

   pT2 vs. pT1

 

2.15 (1.17-3.95)

 

2.36 (1.20-4.65)

 

1.59 (0.82-3.07)

  

   pT3+4 vs. pT1

 

2.81 (1.40-5.62)

 

2.87 (1.30-6.37)

 

2.23 (1.04-4.77)

  

Histological grade

0.091

   

0.768

   

   II vs. I

 

1.54 (0.36-6.58)

   

1.38 (0.32-5.94)

  

   III vs. I

 

2.80 (0.68-11.6)

   

1.76 (0.42-7.44)

  

Number of involved lymph nodes

0.001

 

0.013

 

0.005

 

0.006

 

   1-3 vs. node-negative

 

1.51 (0.89-2.56)

 

1.41 (0.81-2.44)

 

1.39 (0.73-2.65)

 

1.53 (0.80-2.93)

   ≥4 vs. node-negative

 

3.29 (1.84-5.88)

 

2.63 (1.38-5.00)

 

3.32 (1.67-6.64)

 

3.17 (1.56-6.43)

Estrogen receptor statusb

0.245

   

0.845

   

   Positive vs. negative

 

0.77 (0.50-1.19)

   

0.95 (0.55-1.63)

  

Progestrone receptor statusb

0.431

   

0.650

   

   Positive vs. negative

 

0.84 (0.55-1.29)

   

0.89 (0.53-1.48)

  

TRIB3

< 0.001

 

0.009

 

< 0.001

 

< 0.001

 

   Higher vs. lower than median

 

2.15 (1.39-3.31)

 

1.90 (1.17-3.08)

 

3.48 (2.00-6.06)

 

3.90 (2.06-7.37)

  1. a Hazard ratio (95% confidence interval (CI))
  2. b positive defined as > 10 fmol/mg protein