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Table 1 Mammary gland transplantation data and logistic regression analysis

From: The non-protein coding breast cancer susceptibility locus Mcs5a acts in a non-mammary cell-autonomous fashion through the immune system and modulates T-cell homeostasis and functions

MG transplantation dataa Logistic regression analysisb
  S:S S:R R:S R:R Total   Independent Coefficient Pvalue
Transplant MG present 31 72 22 88 213 MG transplantation efficiency Donor effect -0.3502 0.6449
Transplant MG absent 6 11 3 11 31   Recipient effect -0.4372 0.4423
Percentage of MG present 84% 87% 88% 89% 87%   Donor × recipient 0.3389 0.7056
0 carcinomas 15 50 12 66 143     
1 carcinoma 13 17 10 19 59 MG transplant carcinoma
susceptibility
Donor effect -0.2468 0.6588
2 carcinomas 3 4 0 3 10   Recipient effect -0.8855 0.0447c
3 carcinomas 0 1 0 0 1   Donor × recipient 0.0307 0.9629
Percentage of MGs with 1 carcinoma 52% 31% 45% 25% 33%     
  1. aTransplant groups (donor/recipient): S:S, susceptible/susceptible; S:R, susceptible/resistant; R:S, resistant/susceptible; R:R, resistant/resistant. bLogistic regression was used to estimate the effect of donor and recipient and the interaction between donor and recipient for the dependent variables mammary gland (MG) transplantation efficiency (outcome = histologically determined presence or absence of MG development at transplant site) and MG transplant carcinoma susceptibility (outcome = tumor presence or absence at transplant site) in susceptible congenic control and Mcs5a-resistant congenic reciprocal (donor, recipient) transplant groups. cStatistically significant.