Identification of germline alterations of the mad homology 2 domain of SMAD3 and SMAD4 from the Ontario site of the breast cancer family registry (CFR)

Table 3 Nucleotide diversity (θ × 10^-4)

Nucleotide Diversity (θ) × 10^-4 (Std Dev)
	SMAD3		SMAD4		Cargill et al. [44]	Halushka et al. [45]	Ten Asbroek et al. [46]
	Cases	Controls	Cases	Controls
Non-coding	13.24 ± 7.02	11.24 ± 4.00	7.56 ± 3.36	11.71 ± 4.17	5.3 ± 1.33	5.4 ± 1.5 *	5.7 ± 1.9 **
Coding	0	0	3.99 ± 2.91	3.71 ± 2.69	5.43 ± 1.36	4.5 ± 1.2 *	2.00 ± 0.61
Total	3.54 ± 1.88	8.23 ± 2.93	6.18 ± 2.44	8.61 ± 2.86	5.39 ± 1.36	8.27 ± 1.9	2.00 ± 0.61

Note: Values are mean ± SD. Due to the fact that the Halushka et al. study was split into half African ethnicity and half north American of European descent, only the coding/non-coding data from the European/American samples subset (*) are used for the purpose of this comparison. Please note we used θ in 3' UTR for non-coding data for Ten Asbroek et al. study (**) as they did not perform any analysis on intronic sequences.

ISSN: 1465-542X