Allele-specific regulation of FGFR2 expression is cell type-dependent and may increase breast cancer risk through a paracrine stimulus involving FGF10

Table 6 Genotype distribution of four SNPs in FGFR2^a

rs2981582	rs2981578	rs10736303	rs7895676	Number of patients
CT	AG	AG	CT	29
TT	GG	GG	CC	22
CC	AA	AA	TT	21
CT	GG	GG	CC	7
CC	AG	AG	CT	5
TT	AA	AA	TT	1
Total				85^b

^aFGFR2: fibroblast growth factor receptor 2 gene. The number of patients who carry each combination of the four genotypes is shown in the right-hand column. Although we have no haplotype information, the genotype distribution shows the strong linkage disequilibrium present within this region. The alleles associated with increased breast cancer risk are rs2981582: T; rs2981578: G; rs10736303: G; and rs7895676: C. ^bFor the remaining13 patients, only rs2981578 was genotyped; of these patients, 5 carried AA, 5 carried AG and 3 carried GG.

ISSN: 1465-542X