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Figure 2 | Breast Cancer Research

Figure 2

From: Analysis of tumor environmental response and oncogenic pathway activation identifies distinct basal and luminal features in HER2-related breast tumor subtypes

Figure 2

HER2 related subgroup 7 is characterized by increased pathway activities of hypoxia and other stresses. (A) Heatmap identifying patterns of oncogenic and micro-environmental pathways activity in the HER2 related tumor subgroups 7 (n = 53) and 10 (n = 59) in the primary dataset of 1,143 tumors; red indicates high predicted pathway activity, blue, low pathway activity. (B) Quantitative assessment of predicted probabilities of microenvironmental conditions in primary dataset demonstrating significantly higher hypoxia (P <0.0001), glucose deprivation (P <0.0001), and acidosis (P <0.0001) but no difference in lactic acidosis levels (P = 0.5140). (C) Heatmap identifying patterns of oncogenic and micro-environmental pathways activity in the HER2 related tumor subgroups 7 (n = 37) and 10 (n = 47) in the validation dataset of 547 tumors; red indicates high predicted pathway activity, blue, low pathway activity. (D) Quantitative assessment of predicted probabilities of microenvironmental conditions in primary dataset demonstrating significantly higher hypoxia (P = 0.0149), glucose deprivation (P <0.0001), and acidosis (P = 0.0008) but no difference in lactic acidosis levels (P = 0.0697).

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