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Table 4 Multivariate Cox regression analysis of CTC and DTC status for metastasis-free and breast cancer-specific survival

From: The prognostic significance of tumour cell detection in the peripheral blood versus the bone marrow in 733 early-stage breast cancer patients

 

Relapse-free survival

Breast cancer-specific survival

Clinical variable

HR

P-value

95% CI

HR

P-value

95% CI

CTC status (†)

1.8

0.043

1.0 to 3.3

1.9

0.032

1.1 to 3.6

DTC status (†)

*

*

*

*

*

*

Lymph nodes (vs pN0)

 

< 0.001

  

< 0.001

 

- pN1

2.2

0.001

1.4 to 3.5

2.6

0.001

1.5 to 4.5

- pN2/3

3.2

< 0.001

1.8 to 5.5

3.8

< 0.001

2.1 to 7.0

Histological grade (vs I)

 

0.053

  

0.049

 

- grade II

2.0

0.094

0.9 to 4.5

1.6

0.324

0.6 to 4.3

- grade III

2.8

0.019

1.2 to 6.8

2.8

0.044

1.0 to 7.7

Tumour size (< 20 mm vs > 20 mm)

1.9

0.002

1.3 to 2.9

2.4

< 0.001

1.5 to 3.8

ER/PR status (‡)

1.7

0.028

1.1 to 2.7

1.9

0.018

1.1 to 3.1

HER2 status (†)

*

*

*

1.8

0.024

1.1 to 3.1

Vascular Invasion (†)

1.6

0.048

1.0 to 2.5

1.8

0.015

1.1 to 3.0

  1. *, not significant in final multivariate model; †, positive versus negative; ‡, both negative versus either or both positive
  2. CI, confidence interval; CTC, circulating tumour cell; DTC, disseminated tumour cell; ER, estrogen receptor; HER2, human epidermal growth factor receptor 2; HR, hazard ratio; PR, progesterone receptor