Skip to main content

Table 3 Stratified relative risks (95% CI) of breast cancer according to quartile of plasma 25(OH)D, NHSII.

From: Plasma 25-hydroxyvitamin D and risk of breast cancer in the Nurses' Health Study II

  

Quartile 1

Quartile 2

Quartile 3

Quartile 4

P-value, test for trend

Age at blood ≤45

Cases/controls

63/139

66/136

70/163

91/169

 
 

Multivariate*

1.00 (ref)

1.07 (0.69 to 1.67)

0.91 (0.58 to 1.41)

1.19 (0.77 to 1.84)

0.51

Age at blood > 45

Cases/controls

78/161

85/169

75/144

85/137

 
 

Multivariate*

1.00 (ref)

1.05 (0.71 to 1.55)

1.06 (0.70 to 1.61)

1.22 (0.80 to 1.85)

0.35

BMI < 25

Cases/controls

77/121

88/149

84/192

109/216

 
 

Multivariate*

1.00 (ref)

0.99 (0.66 to 1.48)

0.75 (0.50 to 1.13)

0.90 (0.60 to 1.33)

0.45

BMI ≥ 25

Cases/controls

64/179

63/156

61/115

67/90

 
 

Multivariate*

1.00 (ref)

1.09 (0.71 to 1.67)

1.45 (0.92 to 2.28)

1.90 (1.19 to 3.03)

0.005

Summer

Cut points

< 21.2

21.2 to < 27.1

27.1 to < 32.7

≥ 32.7

 
 

Cases/controls

73/142

70/142

73/143

71/144

 
 

Multivariate*

1.00 (ref)

0.95 (0.62 to 1.45)

0.99 (0.65 to 1.53)

0.97 (0.63 to 1.52)

0.95

Winter

Cut points

< 16.5

16.5 to < 22.7

22.7 to < 28.4

≥ 28.4

 
 

Cases/controls

71/161

83/159

78/165

94/162

 
 

Multivariate*

1.00 (ref)

1.22 (0.82 to 1.83)

0.98 (0.65 to 1.47)

1.22 (0.81 to 1.82)

0.52

  1. *Multivariate unconditional logistic regression models adjusted for covariates and matching factors listed in Table 2.
  2. P-value, test for heterogeneity: age at blood collection P = 0.29; BMI at blood collection P = 0.01; season of blood collection P = 0.52.
  3. §Cut points in nmol/L are: Summer < 52.9, 52.9 to < 67.6, 67.6 to < 81.6, ≥ 81.6; Winter < 41.2, 41.2 to < 56.7, 56.7 to < 70.9, ≥ 70.9
  4. Abbreviations: 25(OH)D, 25-hydroxyvitamin D; BMI, body mass index; ref, referent