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Table 3 Results of multivariate analysis in Swedish study, overall and stratified by hormone receptor status

From: Coffee consumption modifies risk of estrogen-receptor negative breast cancer

Type of breast cancer

Daily coffee consumption

Controls/Cases

ORa

95% CI

ORbc

95% CI

All

≤ 1 cup

270/298

1.00

reference

1.00

reference

 

> 1 to 3 cups

1,171/,277

1.00

0.83

1.20

1.01

0.84

1.23

 

> 3 to 5 cups

846/904

0.96

0.79

1.16

1.00

0.82

1.22

 

> 5 cups

363/328

0.80

0.64

0.99

0.84

0.66

1.06

 

P trend

 

0.028

0.127

ER-positive

≤ 1 cup

270/161

1.00

reference

1.00

reference

 

> 1 to 3 cups

1,171/685

0.99

0.80

1.23

1.03

0.82

1.30

 

> 3 to 5 cups

846/501

0.99

0.79

1.23

1.07

0.84

1.36

 

> 5 cups

363/169

0.77

0.59

1.00

0.87

0.65

1.15

 

P trend

 

0.065

0.471

ER-negative

≤ 1 cup

270/48

1.00

reference

1.00

reference

 

> 1 to 3 cups

1,171/148

0.74

0.52

1.05

0.77

0.53

1.11

 

> 3 to 5 cups

846/92

0.58

0.40

0.85

0.60

0.40

0.89

 

> 5 cups

363/31

0.44

0.27

0.71

0.43

0.25

0.72

 

P trend

 

0.0002

0.0003

PR-positive

≤ 1 cup

270/135

1.00

reference

1.00

reference

 

> 1 to 3 cups

1,171/603

1.04

0.83

1.31

1.05

0.83

1.34

 

> 3 to 5 cups

846/434

1.01

0.80

1.29

1.09

0.85

1.40

 

> 5 cups

363/144

0.77

0.58

1.02

0.84

0.62

1.13

 

P trend

 

0.055

0.360

PR-negative

≤ 1 cup

270/66

1.00

reference

1.00

reference

 

> 1 to 3 cups

1,171/212

0.75

0.55

1.02

0.85

0.61

1.17

 

> 3 to 5 cups

846/150

0.71

0.52

0.98

0.75

0.53

1.05

 

> 5 cups

363/55

0.59

0.40

0.88

0.67

0.44

1.01

 

P trend

 

0.014

0.034

  1. aOdds ratio (OR) and corresponding 95% confidence intervals (CI) adjusted for matching factor (age at enrolment in years, continuous).
  2. bORs and corresponding 95% CI adjusted for age at enrolment, potential confounders (hormone replacement therapy (HRT), ever/never, ever smoked > 1 y or > 100 cigarettes, and education (elementary school, junior secondary school, high school or university)) and average daily alcohol consumption (g/day).
  3. Significant P values are in bold.
  4. ER, estrogen receptor; PR, progesterone receptor.