Figure 2

Correlations of drug responses and trastuzumab binding capacities. A. Correlation of response to trastuzumab and trastuzumab binding capacity. No significant correlation was found when trastuzumab binding capacities (determined by flow cytometry [40]) were plotted against trastuzumab sensitivities of the breast cancer cell lines (R = 0.43, P = 0.19). Trastuzumab sensitivities are expressed in proportion to the BT-474 cell line. B. Correlation of response to T-DM1 and trastuzumab binding capacity. No significant correlation was found when trastuzumab binding capacities were plotted against T-DM1 sensitivities of the breast cancer cell lines (R = 0.58, P = 0.06). T-DM1 sensitivities are expressed in proportion to the BT-474 cell line. C. Correlation of trastuzumab and T-DM1 responses. Effects of both drugs on breast cancer cell lines were plotted. No significant correlation was found between the responsiveness to trastuzumab and T-DM1 (R = 0.6, P = 0.07). Drug sensitivities are expressed in proportion to the BT-474 cell line.