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Figure 6 | Breast Cancer Research

Figure 6

From: Prospective isolation and characterization of committed and multipotent progenitors from immortalized mouse mammary epithelial cells with morphogenic potential

Figure 6

Hypothetical model of stem cell differentiation during mammary gland development. Mammary gland development begins by asymmetric self-renewal in a stem cell, which generates multipotent and bipotent ductal and alveolar progenitor cells. Ductal and alveolar progenitor cells are bipotent, express high CK5 levels and may give rise to luminal and myoepithelium-restricted progenitors. Upon commitment to transient amplification and differentiation, restricted progenitor cells may downregulate CK5 expression.

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Breast Cancer Research

ISSN: 1465-542X

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