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Figure 4 | Breast Cancer Research

Figure 4

From: Synergy between inhibitors of androgen receptor and MEK has therapeutic implications in estrogen receptor-negative breast cancer

Figure 4

Synergistic induction of apoptosis by AR and MEK inhibitors in HCC-202 cell line. (A) Histogram showing the percentage of apoptosis (P1) in control (solvent-only treated) HCC-202 cell line using annexin V-FITC flow cytometry. (B) Histogram showing the percentage of apoptosis following CI-1040 treatment at 30 μM (CI-30 μM) in HCC-202 cell line. (C) Histogram showing the percentage of apoptosis following flutamide (FLU) treatment at 80 μM in HCC-202 cell line. (D) Histogram showing the percentage of apoptosis following combination therapy with CI-1040 at 10 μM and flutamide at 30 μM in HCC-202 cell line. CI is calculated using the concentrations of monotherapies with these agents as shown in Figures 4B and 4C that induced a level of apoptosis similar to that of combination therapy.

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Breast Cancer Research

ISSN: 1465-542X

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