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Table 1 Selected ontologies of commonly upregulated genes

From: The indole-3-carbinol cyclic tetrameric derivative CTet inhibits cell proliferation via overexpression of p21/CDKN1A in both estrogen receptor-positive and triple-negative breast cancer cell lines

Term

Genesa

Gene set on the array

Z-score

Biological process

   

   Response to stimulus

39

3,137

4.82

   Response to stress

27

1,753

5.05

   Response to unfolded proteinb

3

62

4.14

   Acute inflammatory responseb

5

99

5.5

   Acute-phase responseb

4

43

7.11

   Regulation of acute inflammatory responseb

3

26

6.95

   Response to chemical stimulus

21

1,396

4.26

   Response to organic substanceb

15

845

4.25

   Response to hormone stimulusb

10

440

4.35

   Response to steroid hormone stimulusb

7

220

4.75

   Response to glucocorticoid stimulusb

6

94

6.98

   Leukocyte chemotaxisb

3

60

4.23

   Response to oxygen levelsb

5

151

4.12

   Response to toxinb

3

64

4.05

   Response to extracellular stimulus

7

242

4.41

   Positive regulation of response to external stimulusb

4

87

4.63

   Cellular response to extracellular stimulusb

5

82

6.19

   Cellular response to nutrient levelsb

4

62

5.73

   Cellular response to starvationb

3

43

5.2

   Response to biotic stimulus

10

424

4.49

   Response to virusb

6

147

5.24

   Cell death

24

1,227

6.04

   Apoptosis

22

1,116

5.8

   Regulation of cell deathb

17

872

4.99

   Regulation of apoptosisb

16

859

4.62

   Negative regulation of cell deathb

10

402

4.69

   Negative regulation of apoptosisb

9

391

4.16

   Induction of apoptosisb

8

333

4.06

   Anti-apoptosisb

8

226

5.49

   Positive regulation of anti-apoptosisb

3

32

6.18

   Cellular component disassembly involved in apoptosisb

3

27

6.81

   Release of cytochrome c from mitochondriab

3

24

7.27

   Protein folding

6

158

4.99

   Leukocyte migration

4

86

4.66

   Autophagy

3

48

4.86

   Regulation of synaptic plasticity

3

57

4.37

   Iron ion homeostasis

4

31

8.54

   Positive regulation of smooth muscle cell proliferation

3

28

6.67

   Regulation of viral reproduction

3

28

6.67

Cellular component

   

   Integral to membrane

9

4,459

-4.27

   Autophagic vacuole

3

20

8.2

Molecular functions

   

   Heat-shock protein binding

5

71

7.14

   Unfolded protein binding

5

103

5.69

   Antioxidant activity

3

45

5.35

  1. aNumber of genes differentially expressed within the assigned ontology. bSubcategory within a given ontology.