Figure 1From: The indole-3-carbinol cyclic tetrameric derivative CTet inhibits cell proliferation via overexpression of p21/CDKN1A in both estrogen receptor-positive and triple-negative breast cancer cell linesSynthesis of CTet. Homo-coupling of 2,3'-DIM in the presence of formaldehyde in acidic conditions is shown. Methanol was the solvent, and the mixture was refluxed for 1 hour in the dark. CTet, indole-3-carbinol cyclic tetrameric derivative.Back to article page