From: Estrogen receptor-beta sensitizes breast cancer cells to the anti-estrogenic actions of endoxifen
 | MCF7 Parental Cells |  |  |
---|---|---|---|
Pathway # | Pathway Name | P-Value | # Genes |
1* | Immune response_Antiviral actions of Interferons | 0.0008 | 6/20 |
2* | Immune response_IFN gamma signaling pathway | 0.0177 | 6/36 |
3 | Regulation of lipid metabolism_Regulation of fatty acid synthase activity | 0.0182 | 3/10 |
4 | Neurodisease_Parkin disorder under Parkinson disease | 0.0191 | 4/18 |
5* | Regulation of lipid metabolism_Regulation of acetyl-CoA carboxylase 1 | 0.0195 | 2/4 |
6* | Cholesterol Biosynthesis | 0.0276 | 4/20 |
7* | Niacin-HDL metabolism | 0.0305 | 3/12 |
8* | Cytoskeleton remodeling_Thyroliberin in cytoskeleton remodeling | 0.0305 | 3/12 |
9 | CFTR-dependent regulation of ion channels in Airway Epithelium | 0.0326 | 4/21 |
10 | Immune response_IL-27 signaling pathway | 0.0380 | 3/13 |
11* | Development_A1 receptor signaling | 0.0440 | 4/23 |
12* | Neurophysiological process_PGE2-induced pain processing | 0.0450 | 2/6 |
13* | Immune response_Th1 and Th2 cell differentiation | 0.0463 | 3/14 |
 | MCF7-ERβ Cells |  |  |
1* | wtCFTR and deltaF508 traffic/Membrane expression (norm and CF) | 0.0026 | 5/16 |
2 | Regulation of lipid metabolism_Regulation of fatty acid synthase activity | 0.0026 | 4/10 |
3 | Immune response_IL-27 signaling pathway | 0.0077 | 4/13 |
4* | Blood coagulation_Blood coagulation | 0.0132 | 4/15 |
5* | Cell cycle_ERα regulation of G1/S transition | 0.0167 | 5/24 |
6* | Globo-(isoglobo) series GSL Metabolism | 0.0228 | 3/10 |
7 | Neurodisease_Parkin disorder under Parkinson disease | 0.0254 | 4/18 |
8* | ERα action on cytoskeleton remodeling and cell migration | 0.0299 | 3/11 |
9* | Transcription_Ligand-Dependent Transcription of Retinoid-Target genes | 0.0306 | 4/19 |
10* | ENaC regulation in airways (normal and CF) | 0.0364 | 4/20 |
11 | CFTR-dependent regulation of ion channels in Airway Epithelium | 0.0427 | 4/21 |
12* | wtCFTR and delta508-CFTR traffic/Generic schema (norm and CF) | 0.0463 | 5/31 |