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Table 1 Biological pathways regulated by estrogen plus 40 nM endoxifen relative to estrogen treatment alone

From: Estrogen receptor-beta sensitizes breast cancer cells to the anti-estrogenic actions of endoxifen

 

MCF7 Parental Cells

  

Pathway #

Pathway Name

P-Value

# Genes

1*

Immune response_Antiviral actions of Interferons

0.0008

6/20

2*

Immune response_IFN gamma signaling pathway

0.0177

6/36

3

Regulation of lipid metabolism_Regulation of fatty acid synthase activity

0.0182

3/10

4

Neurodisease_Parkin disorder under Parkinson disease

0.0191

4/18

5*

Regulation of lipid metabolism_Regulation of acetyl-CoA carboxylase 1

0.0195

2/4

6*

Cholesterol Biosynthesis

0.0276

4/20

7*

Niacin-HDL metabolism

0.0305

3/12

8*

Cytoskeleton remodeling_Thyroliberin in cytoskeleton remodeling

0.0305

3/12

9

CFTR-dependent regulation of ion channels in Airway Epithelium

0.0326

4/21

10

Immune response_IL-27 signaling pathway

0.0380

3/13

11*

Development_A1 receptor signaling

0.0440

4/23

12*

Neurophysiological process_PGE2-induced pain processing

0.0450

2/6

13*

Immune response_Th1 and Th2 cell differentiation

0.0463

3/14

 

MCF7-ERβ Cells

  

1*

wtCFTR and deltaF508 traffic/Membrane expression (norm and CF)

0.0026

5/16

2

Regulation of lipid metabolism_Regulation of fatty acid synthase activity

0.0026

4/10

3

Immune response_IL-27 signaling pathway

0.0077

4/13

4*

Blood coagulation_Blood coagulation

0.0132

4/15

5*

Cell cycle_ERα regulation of G1/S transition

0.0167

5/24

6*

Globo-(isoglobo) series GSL Metabolism

0.0228

3/10

7

Neurodisease_Parkin disorder under Parkinson disease

0.0254

4/18

8*

ERα action on cytoskeleton remodeling and cell migration

0.0299

3/11

9*

Transcription_Ligand-Dependent Transcription of Retinoid-Target genes

0.0306

4/19

10*

ENaC regulation in airways (normal and CF)

0.0364

4/20

11

CFTR-dependent regulation of ion channels in Airway Epithelium

0.0427

4/21

12*

wtCFTR and delta508-CFTR traffic/Generic schema (norm and CF)

0.0463

5/31