From: Signaling pathways in breast cancer metastasis - novel insights from functional genomics
Study | Signature | Size (genes) | Type | Validation |
---|---|---|---|---|
van 't Veer et al. [15] | Poor prognosis | 70 | Classifier | Clinical |
Wang et al. [17] | Poor prognosis | 76 | Classifier | Clinical |
Ramaswamy et al. [20] | General metastasis | 128 | Classifier | Clinical |
Chang et al. [34] | Wound healing | 512 | Physiological response | Clinical |
Finak et al. [37] | Stromal | 26 | Classifier | Clinical |
Troester et al. [38] | Stromal | 155 | Classifier | Clinical |
Farmer et al. [39] | Stromal | 50 | Classifier, metagene | Clinical |
Chi et al. [42] | Epithelial hypoxia | 168 | Physiological response | In vitro, clinical |
Winter et al. [44] | Hypoxia | 99 | Classifier, metagene | Clinical |
Buffa et al. [41] | Hypoxia | 51 | Classifier, metagene | Clinical |
Hu et al. [43] | VEGF | 13 | Classifier | Clinical |
Kang et al. [23] | Bone metastasis | 102 | Tissue tropism | Animal |
Minn et al. [24] | Lung metastasis | 95 | Tissue tropism | Animal, clinical |
Bos et al. [22] | Brain metastasis | 243 | Tissue tropism | Animal, clinical |
Bild et al. [50] | Myc, E2F3, Ras, Src, β-catenin | 248, 298, 348, 73, 98 | Signaling pathway | Clinical, in vitro |
Nguyen et al. [52] | WNT in lung cancer | 81 | Signaling pathway | Animal, clinical |
Padua et al. [55] | TGF-β [53] | 153 | Signaling pathway | Animal, clinical |
Zhang et al. [54] | Src [50] | 172 | Signaling pathway | Animal, clinical |