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Table 2 Cox analysis of recurrence-free and overall survival according to HMG-CoAR mRNA expression in Cohort I

From: Tumor-specific HMG-CoA reductase expression in primary premenopausal breast cancer predicts response to tamoxifen

 

Recurrence-free survival

Overall survival

 

Univariate

Multivariatea

Univariate

Multivariatea

 

HR

95% CI

P value

HR

95% CI

P value

HR

95% CI

P value

HR

95% CI

P value

HMG-CoAR mRNA (continuous)

0.64

0.48 to 0.85

0.002

0.63

0.45 to 0.89

0.009

0.55

0.41 to 0.75

<0.001

0.49

0.32 to 0.75

0.001

Size (continuous)

1.02

0.99 to 1.05

0.175

1.02

0.97 to 1.07

0.439

0.99

0.96 to 1.04

0.89

0.98

0.93 to 1.04

0.581

Grade (I and II vs. III)

2.62

1.62 to 4.23

<0.001

3.13

1.80 to 5.44

<0.001

2.95

1.70 to 5.14

<0.001

4.32

2.22 to 8.41

<0.001

Nodal status (negative vs. positive)

2.80

1.44 to 5.42

0.002

1.13

1.10 to 1.21

<0.001

5.49

2.29-13.17

<0.001

1.12

1.04 to 1.20

0.004

Age (continuous)

1.02

0.99 to 1.04

0.23

0.99

0.96 to 1.03

0.700

1.01

0.98 to 1.04

0.599

0.99

0.95 to 1.03

0.566

  1. CI, confidence interval; HMG-CoAR, 3-hydroxy-3-methylglutharyl-coenzyme A reductase; HR, hazard ratio. aAdjusted for all other variables in the table.