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Figure 1 | Breast Cancer Research

Figure 1

From: Tumor-specific HMG-CoA reductase expression in primary premenopausal breast cancer predicts response to tamoxifen

Figure 1

HMG-CoAR expression is associated with tamoxifen response in vitro. (a) Western blot demonstrating increased expression of 3-hydroxy-3-methylglutharyl-coenzyme A reductase (HMG-CoAR) in tamoxifen-sensitive MCF7 cells compared with their tamoxifen-resistant derivatives LCC9. (b) Quantitative reverse transcriptase PCR demonstrating increased expression of HMG-CoAR mRNA in MCF7 cells compared with LCC9 cells. (c) Immunohistochemistry demonstrating increased HMG-CoAR protein expression in MCF7 cells compared with LCC9 cells. (d) MTT assay demonstrating improved tamoxifen response in MCF7 cells compared with LCC9 cells.

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