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Figure 5 | Breast Cancer Research

Figure 5

From: Enhanced RAD21 cohesin expression confers poor prognosis and resistance to chemotherapy in high grade luminal, basal and HER2 breast cancers

Figure 5

Effect of shRNA-mediated RAD21 knockdown on cellular sensitivity to anti-cancer drugs. Independent cell clones with stably reduced RAD21 expression were derived from the breast cancer cell line, MDA-MB-231. Relative levels of RAD21 gene expression when compared to the parental line by qRT-PCR and semi-quantitative Western blot analysis were shown in Figure 4. Error bar = SEM. Clonogenic survival following treatment with: A. cyclophosphamide: sh223_sc1 (P = 0.0316), sh223_sc3 (P = 0.175), sh224_sc4 (P = 0.0187) and sh224_sc5 (P = 0.0563); B. 5-FU: sh223_sc1 (P = 0.020), sh224_sc4 (P = 0.0257) and sh224_sc5 (P = 0.0242); and C. etoposide: sh223_sc1 (P = 0.020) and sh224_sc5 (P = 0.042).

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