Figure 1

Metastasis-free survival as a function of dichotomized DC-SCRIPT. Metastasis-free survival is shown as a function of dichotomized DC-SCRIPT in 837 lymph-node negative, primary breast cancer patients after subdividing them according high and low ESR1 and ESR2 in the primary tumor and tumor size. (a) ESR1 negative primary breast tumors, (b) ESR1 positive primary breast tumors, (c) ESR1 positive pT1 primary breast tumors, (d) ESR2 low primary breast tumors, (e) ESR2 high primary breast tumors, (f) ESR2 low pT1 primary breast tumors. Quantitative polymerase chain reaction cut points are shown for high versus low DC-SCRIPT (66.7% versus 33.3%) [7], for positive versus negative ESR1 (0.2) [14], and for ESR2-low versus -high at the median level of 0.005 (mRNA levels relative to reference gene set). Patients at risk are indicated. DC-SCRIPT, dendritic cell-specific transcript; ESR, estrogen receptor; pT1, small tumor without lymphatic/vascular invasion.