Figure 1

Deficiency of Mena increases tumor latency and decreases morbidity. A. Percent of mice without palpable tumors at the given age. N >100 mice/genotype. P-values by Log-rank (Mantel-Cox) test: Mena WT vs. Het = 0.02, Mena WT vs. Null <0.0001, Mena Het vs. Null <0.0001. B. Kaplan Meir curve measuring percentage of mice from each genotype that are not moribund (mice that have not yet developed tumors or mice that have small tumors that have not immobilized them). N = 12 to 25 mice/genotype. P-values by Log-rank (Mantel-Cox) test: Mena WT vs. Het = 0.44, Mena WT vs. Null = 0.01, Mena Het vs. Null = 0.05. C. Average number of tumors per mouse at 10 weeks of age. N = 25 mice/genotype. Error bars indicate SEM. P-values by student's t-test are listed above columns. D. Average tumor size at given age. Tumors measured with digital calipers. For each genotype N = 5 mice/given age. Error bars indicate SEM. P-values by student's t-test for Mena WT vs. Mena Null at 8 weeks = 0.033, at 10 weeks = 0.034, all other P-values > 0.05.